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1.
Arkh Patol ; 59(1): 46-50, 1997.
Article in Russian | MEDLINE | ID: mdl-9139608

ABSTRACT

Short-term hypoxia produces ultrastructural alterations in ganglions of rats in the form of dilatation of some membrane neuron compartments and sinuous plasmatic membrane. More long-term hypoxia produces structural changes of membrane cell components. An increase of lysosome number and lipofuscin granules alternations in chronic hypoxia (1 year) are similar to the age changes and are characterized by intensive accumulation of lipofuscin and Nissl bodies hypertrophy.


Subject(s)
Hypoxia/pathology , Stellate Ganglion/ultrastructure , Aging/pathology , Animals , Chronic Disease , Hypertrophy/pathology , Lipofuscin/analysis , Lysosomes/pathology , Male , Nissl Bodies/pathology , Rats , Rats, Wistar
2.
Arkh Patol ; 59(6): 61-5, 1997.
Article in Russian | MEDLINE | ID: mdl-9483223

ABSTRACT

Immunohistochemical investigation of NO-synthase in brain astrocytic tumors revealed intense reaction in many tumor cells as well as direct correlation in the intensity of reaction and the degree of tumor anaplasia. Grade I astrocytomas did not show immunoreactivity in contrast to high anaplastic tumors where many cells had positive reaction with a different degree of intensity. Positive immunoreaction was shown in many giant cells. Small cell glioblastomas and oligodendrogliomas were immunonegative. There was a direct correlation between NO-synthase expression and glial fibrillar acidic protein.


Subject(s)
Astrocytoma/enzymology , Brain Neoplasms/enzymology , Glioblastoma/enzymology , Nitric Oxide Synthase/analysis , Humans , Immunohistochemistry
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