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1.
Blood basophils and asthma among participants from CONSTANCES, the French population-based cohort.
Nadif, Rachel; Henny, Joseph; Tsiavia, Tajidine; Ribet, Céline; Goldberg, Marcel; Zins, Marie; Orsi, Laurent; Roche, Nicolas.
Allergy ; 79(9): 2527-2531, 2024 Sep.
Article in English | MEDLINE | ID: mdl-38425050

Subject(s)
Asthma , Basophils , Humans , Asthma/epidemiology , Asthma/immunology , France/epidemiology , Basophils/immunology , Female , Male , Cohort Studies , Adult , Middle Aged
2.
Blood inflammatory phenotypes were associated with distinct clinical expressions of asthma in adults from a large population-based cohort.
Tsiavia, Tajidine; Henny, Joseph; Goldberg, Marcel; Zins, Marie; Roche, Nicolas; Orsi, Laurent; Nadif, Rachel.
EBioMedicine ; 76: 103875, 2022 Feb.
Article in English | MEDLINE | ID: mdl-35152149

ABSTRACT

BACKGROUND: Asthma is an inflammatory heterogeneous disease. Asthma inflammatory phenotypes based on blood eosinophil and neutrophil counts have never been identified and characterized in population-based studies. METHODS: Adults with current asthma and available blood eosinophil and neutrophil counts from the French population-based CONSTANCES cohort were included. Current asthma was defined by reports of asthma attacks, symptoms or treatments in the last 12 months. Inflammatory phenotypes were based on low (L) and high (H) blood (B) eosinophil (E) (LBE/HBE:

Subject(s)
Asthma , Eosinophils , Female , Humans , Leukocyte Count , Male , Neutrophils/metabolism , Phenotype
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