ABSTRACT
Systemic leucocyte-induced oxidative stress in prolonged occupational exposure to dust modifies oxidative metabolism of neutrophils and RBC, causes inflammatory and destructive, autoimmune processes in gastric lining and possible subsequent occupational gastropathies. To verify gastropathies caused by technogenic dust aerosols, search of preclinical biologic markers of gastric lining damage is essential. The article presents main steps in occupational gastropathies formation, trigger mechanisms, leading pathogenetic factors of gastric lining damage and of atrophic fundus gastritis. Using the mentioned complex of biomarkers in gastric lining state monitoring among workers at periodic and thorough medical examination is main item in forecasting individual risk of occupational gastropathies and in possible approach to their prevention and treatment.
Subject(s)
Air Pollutants, Occupational/toxicity , Dust , Gastric Mucosa/drug effects , Gastritis, Atrophic/chemically induced , Occupational Diseases/chemically induced , Workplace/standards , Air Pollutants, Occupational/analysis , Autoantibodies/blood , Biomarkers/analysis , Erythrocytes/drug effects , Erythrocytes/metabolism , Gastric Mucosa/immunology , Gastric Mucosa/metabolism , Gastric Mucosa/pathology , Gastritis, Atrophic/immunology , Gastritis, Atrophic/metabolism , Gastritis, Atrophic/pathology , Humans , Male , Middle Aged , Neutrophils/drug effects , Neutrophils/metabolism , Occupational Diseases/immunology , Occupational Diseases/metabolism , Occupational Diseases/pathology , Oxidative Stress/drug effects , Risk FactorsABSTRACT
The authors present main mechanisms and leading pathogenetic factors underlying occupationally mediated dust nephropathies. The article covers results of analysis concerning biochemical and hemocoagulation criteria to evaluate the risk of nephropathy in workers exposed to high concentrations of industrial dust aerosols.
Subject(s)
Biomarkers/blood , Dust/analysis , Hemostasis/drug effects , Kidney Diseases/blood , Occupational Diseases/blood , Occupational Exposure/adverse effects , Blood Platelets/metabolism , Female , Humans , Incidence , Kidney Diseases/chemically induced , Kidney Diseases/epidemiology , Lipid Peroxidation , Male , Middle Aged , Occupational Diseases/epidemiology , Occupational Diseases/etiology , Oxidative Stress , Prognosis , Risk Factors , Siberia/epidemiologyABSTRACT
The authors present results of evaluating molecular genetic markers to estimate individual risk and forecast visceropathies development in workers exposed to high concentrations of industrial dust aerosols.
