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Lancet ; 337(8756): 1511-2, 1991 Jun 22.
Article in English | MEDLINE | ID: mdl-1675372

ABSTRACT

Adoptive immunotherapy may be useful for treating or visualising metastatic cancer. Lymphocytes were taken from 6 patients with metastatic colorectal cancer and cultured with cells from the patients primary tumour to produce tumour-activated killer (TAK) lymphocytes. We re-injected each patient with IIIIn-labelled TAK cells in order to visualise metastases. Images were taken with a gamma-camera for up to 48 h after injection. Metastases were revealed as early as 4 h in the lung and as late as 48 h in the abdomen. Liver images produced "cold" spots corresponding to metastatic lesions. Lymph nodes were not visualised. Re-injection of TAK cells raised against autologous colorectal tumours reveals the sites of metastases.


Subject(s)
Abdominal Neoplasms/diagnostic imaging , Colorectal Neoplasms/diagnostic imaging , Indium Radioisotopes , Lung Neoplasms/diagnostic imaging , Lymphocytes, Tumor-Infiltrating/diagnostic imaging , Abdominal Neoplasms/secondary , Aged , Female , Humans , Lung Neoplasms/secondary , Male , Middle Aged , Radionuclide Imaging
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