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Eksp Klin Farmakol ; 70(3): 25-8, 2007.
Article in Russian | MEDLINE | ID: mdl-17650628

ABSTRACT

The chronic experiments on dogs with a pancreatitis model showed that reamberin involved in a complex therapy is conductive to timely positive clinical and laboratory dynamics of disease, particularly to the correction of lipid-induced distress syndrome, and leads to a significant decreasing in the incidence of pancreonecrosis. The positive effect of vitamin E is manifested to a lower degree. The lipid-controlling effect of antioxidants is realized due to a decrease not only in lipid peroxidation rate, but in the phospholipase A2 activity as well.


Subject(s)
Antioxidants/therapeutic use , Pancreatitis, Acute Necrotizing/prevention & control , Pancreatitis/drug therapy , Succinates/therapeutic use , alpha-Tocopherol/therapeutic use , Acute Disease , Animals , Disease Models, Animal , Dogs , Drug Therapy, Combination , Lipid Peroxidation/drug effects , Phospholipases/metabolism
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