ABSTRACT
The authors developed an artificial liver apparatus that comprised 2 running classifiers of blood or one running classifier and mass exchanger. The functionally active link of the apparatus is a suspension of living isolated xenohepatocytes obtained from the liver of pigs weighing 18-20 kg by a combined enzymatic and mechanical procedure. More than 100 in vivo laboratory experiments and 30 operations were performed in 20 patients with acute and chronic hepatic failure. Three patients died, the remaining showed significantly better biochemical parameters of blood and full recovery or stable remission.
Subject(s)
Artificial Organs , Liver , Adolescent , Adult , Female , Humans , Liver Diseases/therapy , Male , Middle AgedABSTRACT
The article describes four design variants of the "auxiliary liver" apparatus which consists of the blood passage fractionators or plasma filters and an original mass transfer device. Indications for using this or that variant of the apparatus have been determined in relationship to the patient's weight and concomitant complications. Clinical examples are given.
Subject(s)
Hemofiltration/instrumentation , Liver Diseases/therapy , Equipment Design , Humans , USSRABSTRACT
The article gives a generalized experience of using the home equipment for gravitational plasma- and cytapheresis for correcting the disturbances of the aggregate state of the blood in acute myocardial infarction, angina pectoris and rheumatic fever. The possibility of a wide-scale use of these devices in the intensive therapy and resuscitation departments has been shown. The basic tenets of the extracorporeal theory of regulating the aggregate state of blood have been formulated. A possibility of the combined use of blood fractionaters with other equipment for changing biochemical, biophysical and cytologic properties of blood has been shown.
