[Influence of Hepatomax on male fertility].

The features of morphotype sperm in men with infertility and found some monomodal its deviations. The study of products of lipid peroxidation (LPO) and antioxidant enzymes (AOP) levels in men with mild forms of chronic inflammation of the urogenital tract complicated with infertility. The studies found that the majority of men surveyed marked activation of lipid peroxidation of biological membranes, which was accompanied by increased concentrations of the major metabolite of LPO--intermediate (conjugated diene) and final (malondialdehyde) in serum. In the study of the system of AOP was found that the activity of catalase and superoxide dismutase decreased. Was calculated as an integrative index F, which characterizes the ratio of prooxidant and antioxidant properties of blood. Found suppression of the index, which indicates an imbalance indicators LPO/AOP. A negative correlation between the index F and the presence of mikrosomatich form sperm was found. The positive influence of the Hepatomax on the process of recovery oxidative activity systems, normalization of the integral index of F and reduce the number of abnormal forms of generative cells was established. Given antioxidant, immunomodulating, hepatoprotective properties of the Hepatomax, we consider it appropriate to include this drug in treatment of infertile men with inflammatory processes in the urogenital tract.

[Studying the dynamics of the levels CD4+CD25+, CD4+ HLA-DR4 + and CD4+CD95+ cells in the semen of men with oligosymptomatic forms of chronic urogenital infection complicated infertility under the influence of fortege].

The markers of activating of lymphocytes in sperm of men with the oligosymptomatic forms of chronic urogenital infection depending on fertility. It is set that the increasing of correlation of CD25/CD95 brings to growth of pathological forms of spermatozoa and, consequently, to the decline of impregnating ability of men. Fortege application leads to the normalization of this correlation and a reduction of pathological forms of sperm and thus to the increasing of the fertilizing potential.

[Influence of immunocorrection on the inflammatory process in the urogenital tract in men with infertility].

We studied the concentration of metalloproteinases, pro-and anti-inflammatory cytokines, lymphocyte activation markers in seminal plasma of men with oligosymptomatic forms of chronic inflammation of the urogenital tract complicated with infertility. It was shown that chronic inflammation of the urogenital tract shifts the levels of cytokine profile, reduces the concentration of metalloproteinase-2 (576.4 +/- 89.3 ng/ml, P < 0.001), chemokines - fractalkine (16.3 +/- 1.3 pg/ml, P < 0.001) and chemmmokine regulated by activation, expression and secretion of normal T-cells (RANTES (12.7 +/- 1.0 pg/ ml, P < 0.001). Additionally, we observed a sharp increase in IL-8 (215.5 +/- 7.8 pg/ml, P < 0.01), MCP-1 (926.4 +/- 30.2 pg/ml, P < 0.001) and elevation of the CD25 + / CD95 + ratio. These observations point for alterations in apoptotic mechanisms in pathological forms of the generative cells and their accumulation in the sperm. Prolonged inflammation of the genital area is accompanied by depletion of the local immune system resulting in the development of infertility. The multidirectional shifts in IL-10/IL-12 index have been established: an increase in the group of patients with elevated level of hypercapitated spermatozoa and its reduction in microsomatic morphotype of spermatozoa. These data emphasize the importance of the microenvironment in maturation of gametes. It was shown that an inclusion of alfagin and gepatomax in immunorehabilitation of men with oligosymptomatic forms of urogenital infections improves leukocyte subpopulation content of sperm and concentrations of pro-and anti-inflammatory cytokines, and therefore, results in an increase in fertilizing potential.

[Influence of phytotherapy on pro- and antioxidant status in spermatozoa, seminal plasma and immunologic status of sperm in men with chronic inflammation of the urogenital tract complicated by infertility].

The lipid peroxidation and antioxidant enzymes in the blood of men with oligosymptomatic forms of chronic inflammation of the urogenital tract complicated by infertility are studied. Studied cytokine status of sperm in infertile men. The positive effect of imupret in combination with gepatomax on the oxidative activity systems, which leads to an improvement of leukocyte subpopulations of sperm, to normalize the concentrations of pro- and anti-inflammatory cytokines, and therefore, an increase in fertilizing are shown.