ABSTRACT
Clinico-instrumental and hormonal investigation of 31 patients with diffuse euthyroid goiter was conducted. To test the efficacy of indometacin as an antigoitrogenic drug, these patients were given it for 2 mos. Combined examination of the patients showed the absence of thyroid decrease and changes in thyroid function against a background of indometacin monotherapy. The results point out to the fact that the drug should not be used for elimination of thyroid hyperplasia in persons with diffuse euthyroid goiter.
Subject(s)
Goiter/drug therapy , Indomethacin/therapeutic use , Adolescent , Adult , Drug Evaluation , Female , Goiter/diagnosis , Humans , Middle Aged , Thyroid Gland/drug effectsSubject(s)
Adrenal Cortex Neoplasms/pathology , Adrenal Gland Neoplasms/pathology , Adrenal Glands/pathology , Cushing Syndrome/pathology , Neoplasms, Germ Cell and Embryonal/pathology , Neoplasms, Multiple Primary/pathology , Pheochromocytoma/pathology , Adrenal Cortex Neoplasms/enzymology , Adrenal Cortex Neoplasms/surgery , Adrenal Gland Neoplasms/enzymology , Adrenal Gland Neoplasms/surgery , Adrenal Glands/enzymology , Adrenalectomy , Cushing Syndrome/enzymology , Cushing Syndrome/surgery , Histocytochemistry , Humans , Hyperplasia/enzymology , Hyperplasia/pathology , Hyperplasia/surgery , Male , Middle Aged , Neoplasms, Germ Cell and Embryonal/enzymology , Neoplasms, Germ Cell and Embryonal/surgery , Neoplasms, Multiple Primary/enzymology , Neoplasms, Multiple Primary/surgery , Pheochromocytoma/enzymology , Pheochromocytoma/surgerySubject(s)
Spectrometry, X-Ray Emission/methods , Thyroid Diseases/diagnosis , Thyroid Function Tests/methods , Adenoma/diagnosis , Graves Disease/diagnosis , Humans , Hypothyroidism/diagnosis , Iodine/analysis , Iodine Radioisotopes , Radionuclide Imaging , Thyroid Diseases/physiopathology , Thyroid Gland/diagnostic imaging , Thyroid Gland/drug effects , Thyroid Gland/physiopathology , Thyroid Gland/radiation effects , Thyroid Neoplasms/diagnosis , Thyroiditis/diagnosisABSTRACT
The paper is concerned with the literature data on pathogenesis and a clinical course of 2 types of PHPT. Clinicolaboratory findings show that PHPT is a polymorphous syndrome of which the most common signs are skeletal changes, low stature, the tetanoid syndrome in hypocalcemia, hyperphosphatemia, the normal or raised level of endogenous PTH, insensitivity to exogenous PTH, soft tissue and brain calcification, mental deficiency. An insufficient or paradoxical PTH reaction and an adequate CT reaction are noted after calcium drug loading. Therapy with I alpha OH D3 and I alpha, 25/OH2 D3 has demonstrated its superiority over other vitamin D forms leading to fast normalization of calcium-phosphoric metabolism and elimination of the tetanoid syndrome.
