[The structure and anthelmintic action of tricyclic analogs of praziquantel and 4-acylpiperazinones-2]. / Stroenie i antigel'mintnaia aktivnost' tritsiklicheskikh analogov prazikvantelia i 4-atsilpiperazinonov-2.

The toxicity and anthelminthic activity of the earlier synthetized tricyclic analogues of praziquantel and 4-acylpiperazinones-2 have been studied. Tricyclic compounds have shown the acute toxicity similar to that of praziquantel and neurotoxic effect typical of praziquantel. 4-acylpiperazinones-2 toxicity correlated with their anthelminthic effect. The determination of anthelminthic activity of the above compounds in opisthorchiasis and hymenolepiasis has shown that they are less effective than praziquantel or have no anthelminthic activity. A biological activity-structure relationship has been traced in the compounds under study.

[Achievements in the search for and creation of Soviet anthelmintic agents]. / Uspekhi v poiske i sozdanii otechestvennykh protivogel'mintnykh sredstv.

Basic achievements in the creation of antinematodal, anticestodal and antitrematodal agents are reviewed chronologically. It is shown that the search was performed mainly among the derivatives of benzimidazole, cyclic amidines, diphenylmethane, salicyl anilides, pyrazine isoquinolines, among natural products of avermictines and milbemicines. It is noted that nowadays there is every possibility for the treatment of mass helminthiases in the USSR. However, it has been found that some drugs are associated with a certain risk and therefore the necessity for further search of safe anthelminthic agents has been emphasized.