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Biochem Biophys Res Commun ; 476(4): 352-358, 2016 08 05.
Article in English | MEDLINE | ID: mdl-27240953

ABSTRACT

An inverse correlation between the morbidity of rheumatoid arthritis and daily intake of ß-cryptoxanthin has been epidemiologically shown. In this study, we investigated the effects of ß-cryptoxanthin on the metabolism of cartilage extracellular matrix in vivo and in vitro. Oral administration of ß-cryptoxanthin (0.1-1 mg/kg) to antigen-induced arthritic rats suppressed the loss of glycosaminoglycans in articular cartilage, which is accompanied by the interference of aggrecanase-mediated degradation of aggrecan. Inhibition of the interleukin 1α (IL-1α)-induced aggrecan degradation by ß-cryptoxanthin was also observed with porcine articular cartilage explants in culture. ß-Cryptoxanthin (1-10 µM) dose-dependently down-regulated the IL-1α-induced gene expression of aggrecanase 1 (ADAMTS-4) and aggrecanase 2 (ADAMTS-5) in cultured human chondrocytes. Moreover, ß-cryptoxanthin was found to augment the gene expression of aggrecan core protein in chondrocytes. These results provide novel evidence that ß-cryptoxanthin exerts anti-arthritic actions and suggest that ß-cryptoxanthin may be useful in blocking the progression of rheumatoid arthritis and osteoarthritis.


Subject(s)
Antirheumatic Agents/pharmacology , Beta-Cryptoxanthin/pharmacology , Cartilage, Articular/drug effects , ADAMTS4 Protein/genetics , ADAMTS4 Protein/metabolism , ADAMTS5 Protein/genetics , ADAMTS5 Protein/metabolism , Aggrecans/metabolism , Animals , Arthritis, Experimental/drug therapy , Cartilage, Articular/pathology , Cells, Cultured , Chondrocytes/drug effects , Chondrocytes/metabolism , Down-Regulation/drug effects , Female , Gene Expression Regulation/drug effects , Humans , Organ Culture Techniques , Rats, Inbred Lew , Swine , Synovial Fluid/cytology
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