1.
Org Lett
; 15(13): 3374-7, 2013 Jul 05.
Article
in English
| MEDLINE
| ID: mdl-23772984
ABSTRACT
A sequential retro-ene arylation reaction has been developed for the conversion of N-alkoxyenamides to the corresponding tert-alkylamines in good yields via the nucleophilic addition of a triarylaluminum reagent to an in situ generated N-acylketimine. The reaction is tolerant of a range of functional groups and provides facile access to a series of tert-alkylamines that would be otherwise difficult to access using conventional procedures.