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Bioorg Med Chem Lett
; 20(15): 4624-6, 2010 Aug 01.
Article
in English
| MEDLINE
| ID: mdl-20573507
ABSTRACT
Quinoline amide, azaindole amide and pyridine amides were synthesized and tested for in vitro antifungal activity against fungi. These synthesized amides have potent antifungal activity against Candida albicans and Aspergillus fumigatus. Our results suggest that hetero ring amides may be potent antifungal agents that operate by inhibiting the function of Gwt1 protein in the GPI biosynthetic pathway.