ABSTRACT
A male neonate with hyperbilirubinaemia and progressing anaemia due to rhesus (c + E) incompatibility received high dose intravenous gammaglobulin (ivIgG) therapy at 13 days of age. Clinical response to therapy was confirmed by a rapid decrease in serum bilirubin level, and with the prevention of a further decline of the haemoglobin level. No side-effects were noted. High dose ivIgG therapy could be an alternative to (exchange) blood transfusion in case of some haemolytic diseases of newborn.
Subject(s)
Immunization, Passive , Immunoglobulin G/administration & dosage , Immunoglobulins, Intravenous/administration & dosage , Rh Isoimmunization/therapy , Humans , Immunoglobulin G/therapeutic use , Immunoglobulins, Intravenous/therapeutic use , Infant, Newborn , Infusions, Intravenous , MaleABSTRACT
For thr purpose of clarifing the role of cultured thymic epithelium (CTE) and dialyzable leukocyte extracts (DLE) in the maturation process of T cells, the effects of the thymic epithelial supernatant (TES) and DLE on cyclic nucleotides in thymocytes were studied. TES increased cAMP levels significantly in thymocytes of mice. The activity of TES to increase cAMP levels correlated well with the state of the growth of thymic epithelium. Moreover, TES increased cAMP levels in human thymocytes, and augumented lymphocyte transformation (LT) to mitogens in immunodeficiency diseases. From these effects, it was suggested that TES had the activities such as thymic hormones. CTE of which TES increased cAMP levels in thymocytes of mice were transplanted in patients with Wiskott-Aldrich syndrome and Ataxia-telangiectasia. After the transplantation, augumentation of LT was observed in both patients. From these results, it was speculated that CTE were engrafted and became to exert its effect in the host. We concluded that it was possible to select the CTE appropriately for transplantation by means of examining the activity of TES. The basal levels of human thymocytes were very low compared with those of peripheral blood lymphocytes (PBL). A significant increase of cAMP levels was observed in thymocytes with stimulation of DLE. DLE produced no significant change of cyclic nucleotide levels in PBL. These results suggested that DLE affected the maturation of human thymocytes with involvement of cAMP. Though DLE was proved to contain histamin and prostaglandin E2, it was revealed from the present study that the active component responsible to increase cAMP levels in human thymocytes was different from these substances. Fractions III and IV of DLE obtained with gel filtration showed the activity to increase cAMP. It was suggested that these fractions contained the active component.
Subject(s)
Cyclic AMP/metabolism , Cyclic GMP/metabolism , T-Lymphocytes/metabolism , Thymus Gland/cytology , Transfer Factor/pharmacology , Acquired Immunodeficiency Syndrome/therapy , Adult , Cells, Cultured , Child , Child, Preschool , Epithelial Cells , Humans , Infant , Lymphocyte Activation , Male , Transfer Factor/therapeutic useABSTRACT
Twenty-three unrelated Japanese patients with asthma who showed a high total serum IgE level, a strong skin test response to Dermatophagoides farinae, and a high score on a radioallergosorbent test (RAST) using Dermatophagoides farinae were typed for HLA-A locus, -B locus, and -D region antigens. No significant difference in the frequencies of HLA-A, -B, and -DR antigens were observed between the asthma patients and the healthy controls. A significant difference in the frequency of MB3', however, was found between the asthma patients and the healthy controls (corrected p = 0.04, relative risk = 18.5).
Subject(s)
Asthma/immunology , Histocompatibility Antigens Class II/immunology , Asthma/epidemiology , Asthma/genetics , Genes, MHC Class II , HLA Antigens/immunology , HLA-B Antigens , HLA-DR Antigens , Humans , Immunoglobulin E/analysis , Japan , Radioallergosorbent TestABSTRACT
The case presented here may be the first identified report of Down syndrome with 21 trisomy in one child of triplets. One triplet died at 1 month of age; his facial appearance was not typical of Down syndrome. Detailed testing of blood groups suggested identical origin in the remaining two children. However, the fluorescent banding technique of chromosome, one-way mixed lymphocyte culture test, and HLA typing were suggestive of dizygotic orgin. Skin transplant studies supported this contention.
