[Genetic polymorphism of haptoglobin and quantitative changes in its levels during exposure to asbestos]. / Geneticheskii polimorfizm gaptoglobina i kolichestvennye izmeneniia v ego soderzhanii pri vozdeistvii asbesta.

The polymorphism and serum levels of haptoglobin were studied in asbestosis patients, in the control and the workers exposed to asbest. Hp1-1 has the highest, Hp2-2--the lowest and Hp2-1 has the intermediate concentration of this protein. In the course of contact with asbest, and especially in asbestosis patients, the haptoglobin levels are higher (for all phenotypes). The standard deviation from the Hp concentration in asbestosis patients was significantly higher. The phenotypes Hp1-1 were found more often in asbestosis patients than among asbest-exposed workers.

[The association of genetic and functional variability of alpha 1-antitrypsin in asbestosis]. / Sopriazhennost' geneticheskoi i funktsional'noi izmenchivosti alpha 1-antitripsina pri asbestoze.

The polymorphism and serum levels of alpha 1-antitrypsin (AT) were studied in asbestosis patients, the control and the workers exposed to mineral flax longer or less than ten years. M1S, M3S, M1Z and M2M2 phenotypes had low concentration of this protein. In the course of contact with mineral flax decrease in alpha 1-AT concentration was found. The phenotypes with low protein levels were very rare among workers contacting with asbestos for a long time, and one of them--M1S was more often encountered in asbestosis patients. The standard deviation from the alpha 1-AT concentration was significantly higher in asbestosis patients.

[Gene manifestations in negative man-made environment: a selective genetically determined sensitivity to asbestos]. / Proiavlenie genov v usloviiakh negativnoi antropogennoi sredy: izbiratel'naia geneticheski obuslovlennaia chuvstvitel'nost' k asbestu.

Genetic polymorphism of the systems of haptoglobin, transferrin, alpha 1-antitrypsin and complement C3 was investigated in patients with asbestosis and in healthy individuals who contacted with asbestos for a long time. The significant differences were discovered between the groups under comparison in the distribution of the phenotypic and genic frequencies in these loci. Simultaneous studies of the levels of these proteins depending on the phenotype demonstrated differentiation of the patients and healthy subjects according to the mean values and dispersions. The data obtained provide evidence in favour of occupational selection as regards the genetic factors investigated.

[Biodemographic parameters as indicators of genetic adaptation to harmful occupational factors (e.g. asbestos)]. / Biodemograficheskie pokazateli kak indikatory geneticheskoi adaptatsii k vrednomu proizvodstvennomu vozdeistviiu (na primere asbesta).

A total of 129 women working at asbestos-concentrating factories and asbestos articles manufacture plant, including 87 of them facing asbestosis and 42 exposed to asbestos without asbestosis were examined. There was no marked shifts in the reproductive function and pregnancy results of women facing asbestosis and those exposed to asbestos without asbestosis. Women facing asbestosis has infant mortality higher than other women. Parameters of potential selection (index Crow) in the studied population showed an unfavourable demographic situation in women facing asbestosis. Analysis of biodemographic data helped to suggest the possibility of genetic predisposition to asbestosis.

[Distribution of ABO, MN, Rh blood groups and Hp, Tr, Gc and C3 serum factors in the Buryat population]. / Raspredelenie grupp krovi ABO, MN, Rh, i syvorotochnykh faktorov Hp, Tf, Gc, i C3 v buriatskikh populiatsiiakh.

Polymorphism of blood groups ABO, MN, Rh and serum proteins Hp, Tf, Gc, C3 was studied in Buryat populations of Zabaikalie, Pribaikalie, Olkhon island. No indication of significant heterogeneity was observed. Gene frequencies varied in different systems within the ranges: ABO (p-0.142-0.183; q-0.205-0.324; r-0.567-0.630); MN (m-0.531-0.624), Rh(d) (0-0.214), Hp (Hp 1-0.268-0.339), C3 (C3F-0.023-0.090), Tf (TfC-0.971-1.0), Gc (Gc1-0.728-0.840). Genetic distances between main Buryat groups were estimated.

[Cytogenetic examination of workers engaged in manufacturing of asbestos technical products]. / Tsitogeneticheskoe obsledovanie rabochikh proizvodstva asbesto-tekhnicheskikh izdelii.

The article contains data on a cytogenetic monitoring of workers engaged in asbestos production, depending on duration of professional service and degrees of dust contamination of the air. The results of the cytogenetic analysis of the peripheral blood lymphocytes in 31 workers revealed the average rate of aberrant cells 1.78% in workers with professional service below 1.5 years, 2.43%--with more than 10 years of service, 2.72%--in the control group (the personnel not engaged in the production). The differences were statistically negligible.