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1.
Kidney Int Rep ; 3(1): 65-72, 2018 Jan.
Article in English | MEDLINE | ID: mdl-29340315

ABSTRACT

INTRODUCTION: Contrast-induced nephropathy is a complication following coronary angiography and percutaneous coronary intervention. Because contrast-induced nephropathy is a predictor of long-term mortality in patients with ischemic heart disease undergoing percutaneous coronary intervention, preventive strategies are required. We assessed the effects of periprocedural oxygenation on contrast-induced nephropathy among patients with pre-existing renal dysfunction. METHODS: A total of 200 consecutive patients with impaired renal function (estimated glomerular filtration < 60 ml/min per 1.73 m2) undergoing elective cardiovascular angiography were randomly assigned to an oxygenation treatment (n = 100) or control group (n = 100). In oxygenation treatment, pure oxygen (2 L/min) was administered for 10 minutes before exposure to contrast medium. The primary endpoint was the incidence of contrast-induced nephropathy, defined as a ≥ 25% increase in serum creatinine levels from baseline within 48 hours of exposure. RESULTS: In the oxygenation treatment group, partial pressure of arterial oxygen was higher (135 ± 25 mm Hg vs. 84 ± 10 mm Hg, P < 0.001); contrast-induced nephropathy incidence was lower (1% vs. 8%, odds ratio [OR] = 0.12, 95% confidence interval [CI] = 0.01-0.95, P = 0.02); and partial pressure of arterial carbon dioxide and bicarbonate base lactate levels were similar compared with those in the control group. Upon univariate analysis, excess and absence of oxygenation treatment (OR = 9.18, CI = 1.13-74.86, P = 0.03) and anemia (OR = 4.30, CI = 1.04-17.78, P = 0.04) were shown to be associated with contrast-induced nephropathy incidence. CONCLUSION: Oxygenation, a simple, nonpharmacological strategy, may be beneficial when using contrast media in patients with impaired renal function from noninvasive angiography to emergency catheterization.

2.
J Interv Cardiol ; 27(3): 252-9, 2014 Jun.
Article in English | MEDLINE | ID: mdl-24450339

ABSTRACT

OBJECTIVE: To determine whether adequate myocardial perfusion status after transluminal recanalization is associated with prompt improvement of QT dispersion (QTd). BACKGROUND: Transluminal recanalization of the infarct-related coronary artery in acute myocardial infarction aims to promptly restore myocardial perfusion, to maximize electrical and mechanical recovery. QTd represents the heterogeneity of ventricular repolarization, which may affect electrical stability. METHODS: Forty patients who underwent primary percutaneous coronary intervention for their first anterior acute ST-elevation myocardial infarction were prospectively enrolled. Myocardial reperfusion status was assessed by myocardial blush grade (MBG) on the final angiogram after successful recanalization (Thrombolysis In Myocardial Infarction Grade 3 flow). RESULTS: Preprocedural QTd was similar in patients with final MBG 0-1, 2, and 3 (76 ± 24, 67 ± 13, and 69 ± 13 milliseconds, respectively; P = 0.661). After recanalization, QTd decreased in patients with MBG 3 (39 ± 16 milliseconds, P < 0.001) but not in patients with MBG 0-1 (74 ± 20 milliseconds) or MBG 2 (82 ± 16 milliseconds). Multivariate analysis showed that postprocedural MBG was an independent predictor of QTd after recanalization (standardized regression coefficient = -0.628, P < 0.001). CONCLUSIONS: Adequate tissue perfusion may be crucial for electrical stability of the myocardium after reperfusion.


Subject(s)
Coronary Vessels , Percutaneous Coronary Intervention/methods , Vascular Patency , Aged , Coronary Angiography/methods , Coronary Vessels/diagnostic imaging , Coronary Vessels/physiopathology , Electrocardiography/methods , Electrophysiological Phenomena , Female , Humans , Male , Middle Aged , Myocardial Infarction/diagnosis , Myocardial Infarction/physiopathology , Myocardial Infarction/therapy , Outcome Assessment, Health Care , Time Factors
4.
Circulation ; 127(1): 63-73, 2013 Jan 01.
Article in English | MEDLINE | ID: mdl-23204107

ABSTRACT

BACKGROUND: CXC-chemokine receptor 4 (CXCR4) regulates the retention of stem/progenitor cells in the bone marrow (BM), and the CXCR4 antagonist AMD3100 improves recovery from coronary ligation injury by mobilizing stem/progenitor cells from the BM to the peripheral blood. Thus, we investigated whether AMD3100 also improves recovery from ischemia/reperfusion injury, which more closely mimics myocardial infarction in patients, because blood flow is only temporarily obstructed. METHODS AND RESULTS: Mice were treated with single subcutaneous injections of AMD3100 (5 mg/kg) or saline after ischemia/reperfusion injury. Three days later, histological measurements of the ratio of infarct area to area at risk were smaller in AMD3100-treated mice than in mice administered saline, and echocardiographic measurements of left ventricular function were greater in the AMD3100-treated mice at week 4. CXCR4(+) cells were mobilized for just 1 day in both groups, but the mobilization of sca1(+)/flk1(+) cells endured for 7 days in AMD3100-treated mice compared with just 1 day in the saline-treated mice. AMD3100 upregulated BM levels of endothelial nitric oxide synthase (eNOS) and 2 targets of eNOS signaling, matrix metalloproteinase-9 and soluble Kit ligand. Furthermore, the loss of BM eNOS expression abolished the benefit of AMD3100 on sca1(+)/flk1(+) cell mobilization without altering the mobilization of CXCR4(+) cells, and the cardioprotective effects of AMD3100 were retained in eNOS-knockout mice that had been transplanted with BM from wild-type mice but not in wild-type mice with eNOS-knockout BM. CONCLUSIONS: AMD3100 prolongs BM progenitor mobilization and improves recovery from ischemia/reperfusion injury, and these benefits appear to occur through a previously unidentified link between AMD3100 and BM eNOS expression.


Subject(s)
Heterocyclic Compounds/pharmacology , Myocardial Reperfusion Injury/drug therapy , Myocardial Reperfusion Injury/metabolism , Nitric Oxide Synthase Type III/metabolism , Receptors, CXCR4/antagonists & inhibitors , Animals , Benzylamines , Bone Marrow Transplantation , Cardiotonic Agents/pharmacology , Cyclams , Disease Models, Animal , Female , Gene Expression Regulation, Enzymologic/drug effects , Hematopoietic Stem Cell Mobilization/methods , Hematopoietic Stem Cells/cytology , Hematopoietic Stem Cells/drug effects , Hematopoietic Stem Cells/physiology , Male , Mice , Mice, Inbred C57BL , Mice, Knockout , Myocardial Infarction/drug therapy , Myocardial Infarction/metabolism , Nitric Oxide Synthase Type III/genetics , Recovery of Function/drug effects , Signal Transduction/drug effects
5.
Proc Natl Acad Sci U S A ; 107(24): 11008-13, 2010 Jun 15.
Article in English | MEDLINE | ID: mdl-20534467

ABSTRACT

We hypothesized that a small molecule CXCR4 antagonist, AMD3100 (AMD), could augment the mobilization of bone marrow (BM)-derived endothelial progenitor cells (EPCs), thereby enhancing neovascularization and functional recovery after myocardial infarction. Single-dose AMD injection administered after the onset of myocardial infarction increased circulating EPC counts and myocardial vascularity, reduced fibrosis, and improved cardiac function and survival. In mice transplanted with traceable BM cells, AMD increased BM-derived cell incorporation in the ischemic border zone. In contrast, continuous infusion of AMD, although increasing EPCs in the circulation, worsened outcome by blocking EPC incorporation. In addition to its effects as a CXCR4 antagonist, AMD also up-regulated VEGF and matrix metalloproteinase 9 (MMP-9) expression, and the benefits of AMD were not observed in the absence of MMP-9 expression in the BM. These findings suggest that AMD3100 preserves cardiac function after myocardial infarction by enhancing BM-EPC-mediated neovascularization, and that these benefits require MMP-9 expression in the BM, but not in the ischemic region. Our results indicate that AMD3100 could be a potentially useful therapy for the treatment of myocardial infarction.


Subject(s)
Bone Marrow Transplantation , Myocardial Infarction/therapy , Receptors, CXCR4/antagonists & inhibitors , Animals , Base Sequence , Benzylamines , Blood Cell Count , Capillaries/drug effects , Capillaries/pathology , Cyclams , DNA Primers/genetics , Endothelial Cells/drug effects , Endothelial Cells/pathology , Female , Hematopoietic Stem Cell Mobilization , Hematopoietic Stem Cells/drug effects , Hematopoietic Stem Cells/pathology , Heterocyclic Compounds/pharmacology , Male , Matrix Metalloproteinase 9/metabolism , Mice , Mice, Inbred C57BL , Mice, Knockout , Mice, Transgenic , Myocardial Infarction/pathology , Myocardial Infarction/physiopathology , Neovascularization, Physiologic/drug effects , Vascular Endothelial Growth Factor A/metabolism
6.
Circ J ; 73(12): 2360-2, 2009 Dec.
Article in English | MEDLINE | ID: mdl-19491509

ABSTRACT

Congenital atresia of the left main coronary ostium is a rare coronary artery anomaly. A 3-year-old boy who was asymptomatic had a heart murmur because of mitral regurgitation. He underwent reconstruction of the left main coronary artery, but stenosis occurred in the early postoperative period. Although the patient underwent repair of the coronary artery stenosis, the distal portion of the left coronary artery re-stenosed. Percutaneous transluminal coronary angioplasty for the stenosis was performed successfully and there has not been any sign of re-stenosis for 30 months to date.


Subject(s)
Angioplasty, Balloon, Coronary , Cardiac Surgical Procedures/adverse effects , Coronary Restenosis/therapy , Coronary Stenosis/surgery , Coronary Vessel Anomalies/surgery , Pericardium/transplantation , Child, Preschool , Coronary Angiography , Coronary Restenosis/diagnostic imaging , Coronary Restenosis/etiology , Coronary Stenosis/diagnostic imaging , Coronary Stenosis/etiology , Humans , Male , Reoperation , Transplantation, Autologous , Treatment Outcome
7.
Atherosclerosis ; 205(2): 376-84, 2009 Aug.
Article in English | MEDLINE | ID: mdl-19193378

ABSTRACT

OBJECTIVE: Although recent clinical trials have suggested that angiotensin II type 1 receptor blockers (ARBs) reduced cardiovascular events, the precise mechanisms involved are still unknown. Telmisartan, an ARB, has recently been identified as a ligand of peroxisome proliferator-activated receptor-gamma (PPARgamma). On the other hand, since endothelial progenitor cells (EPCs) are thought to play a critical role in ischemic diseases, we investigated effects of telmisartan on proliferation of EPCs. METHODS AND RESULTS: Human peripheral blood mononuclear cells were isolated from healthy volunteers, and cultured on fibronectin-coated dishes in the presence or absence of telmisartan. Four days after starting culture, adherent cells were collected, and equal numbers of cells were reseeded into methylcellulose medium with or without telmisartan. In the presence of telmisartan, numbers of colonies increased in a dose-dependent manner. DiI-AcLDL uptake and lectin and CD31, CD34 staining revealed that these colonies were EPCs. Increase in colony number by treatment with telmisartan was absolutely inhibited when cultured with a specific inhibitor of PPARgamma. In addition, we observed that specific inhibitors of phosphoinositide-3 kinase (PI3K) abolished telmisartan-stimulated increase of monocytic EPC-like cells and telmisartan induced phosphorylation of Akt. Furthermore, mRNA expression of p21 was downregulated in a dose dependent manner, suggesting that growth inductive effects of telmisartan might be regulated by the PI3K/Akt and p21 signaling pathway. CONCLUSIONS: These findings suggest that telmisartan might contribute to endothelial integrity and vasculogenesis in ischemic regions by increasing numbers of EPCs.


Subject(s)
Angiotensin-Converting Enzyme Inhibitors/pharmacology , Benzimidazoles/pharmacology , Benzoates/pharmacology , Endothelial Cells/cytology , PPAR gamma/metabolism , Phosphatidylinositol 3-Kinases/metabolism , Proto-Oncogene Proteins c-akt/metabolism , Stem Cells/cytology , Adult , Cell Proliferation , Cellular Senescence , Humans , Ischemia/pathology , Leukocytes, Mononuclear/cytology , Ligands , Male , Telmisartan
9.
Circ J ; 72(10): 1640-4, 2008 Oct.
Article in English | MEDLINE | ID: mdl-18756036

ABSTRACT

BACKGROUND: In the present study it was examined whether transthoracic Doppler echocardiography (TTDE) would be useful for noninvasive diagnosis of coronary spastic angina (CSA) by assessing coronary arterial tone in the morning. METHODS AND RESULTS: The study population comprised 21 CSA patients and 27 control subjects. All diagnoses were angiographically confirmed by provocation test using acetylcholine. Coronary flow velocity reserve (CFVR) was measured at the distal left anterior descending artery with a frequency of 5.0 MHz ultrasound at baseline and after sublingual administration of nitroglycerin (NTG). Coronary arterial tone was assessed by obtaining the change of CFVR induced by NTG administration (CFVR(NTG/Pre)). Basal CFVR tended to be lower in CSA patients (2.13+/-0.63, 2.71+/-0.67, respectively, p = 0.05). CFVR after NTG was significantly higher in CSA patients (3.91+/-1.10, 3.07+/-0.74, p = 0.003). The CFVR(NTG/Pre) was significantly higher in CSA patients than in the control subjects (1.90+/-0.49, 1.15+/-0.22, p < 0.0001). Using a cut-off value of 1.4 in CFVR(NTG/Pre), the sensitivity and specificity for the diagnosis of CSA were 91% and 90%, respectively. CONCLUSION: TTDE appeared to be useful for the noninvasive diagnosis of CSA by assessing the coronary arterial tone.


Subject(s)
Acetylcholine/administration & dosage , Angina Pectoris/diagnostic imaging , Coronary Angiography/methods , Coronary Vessels/diagnostic imaging , Adult , Aged , Angina Pectoris/chemically induced , Blood Flow Velocity/drug effects , Blood Flow Velocity/physiology , Coronary Circulation/physiology , Echocardiography, Doppler , Female , Humans , Male , Middle Aged , Reference Values
10.
Circ J ; 72(9): 1391-6, 2008 Sep.
Article in English | MEDLINE | ID: mdl-18724011

ABSTRACT

BACKGROUND: Because there is insufficient evidence to support primary percutaneous coronary intervention (PPCI) as the treatment of acute myocardial infarction (AMI), this study elucidated the efficacy of PPCI according to disease severity. METHODS AND RESULTS: Between January 1999 and June 2001, 3,021 AMI patients were registered at Tokyo Women's Medical University and 17 affiliated institutions. Of these, 1,994 patients with ST-elevation AMI were admitted within 12 h of onset. PPCI was performed in 1,143 and 294 were treated conservatively. The 1,437 patients were grouped according to Thrombolysis In Myocardial Infarction-risk score: PPCI was performed in 59.5% of the low-risk group, 61.8% of the moderate-risk group, and 56.2% of the high-risk group. Cardiac death was the primary outcome. In the low-risk group, no significant differences were observed between PPCI and conservative therapy for 30-day and long-term cardiac mortality rates. In the moderate-risk group, the 30-day cardiac mortality rate for PPCI was significantly lower; however, no significant intergroup differences were observed for long-term cardiac mortality. In the high-risk group, 30-day and long-term cardiac mortality for PPCI were significantly more favourable than for conservative therapy (p<0.001 and p=0.0032, respectively). CONCLUSIONS: Although PPCI strongly correlated with low short- and long-term cardiac mortality rates in high-risk AMI patients, no similar correlation was found in low-risk patients.


Subject(s)
Angioplasty, Balloon, Coronary , Myocardial Infarction/mortality , Myocardial Infarction/therapy , Aged , Aged, 80 and over , Female , Follow-Up Studies , Humans , Male , Middle Aged , Retrospective Studies , Risk Factors , Severity of Illness Index , Survival Rate , Time Factors , Tokyo
11.
Circ J ; 72(2): 179-85, 2008 Feb.
Article in English | MEDLINE | ID: mdl-18219150

ABSTRACT

BACKGROUND: Outcomes after percutaneous coronary intervention (PCI) for patients with acute myocardial infarction (AMI) complicated by renal insufficiency have not been well described. The aims of this study were to evaluate the association of estimated glomerular filtration rate (GFR) and risk of unsuccessful PCI for AMI, and to evaluate the prognostic importance of PCI success in patients with renal insufficiency. METHODS AND RESULTS: From the Heart Institute of Japan Acute Myocardial Infarction (HIJAMI) registry, 1,706 patients undergoing primary PCI were analyzed. The adjusted odds ratios for unsuccessful PCI of GFR 30-60 and <30 ml . min(-1) . 1.73 m(-2) were 1.97 (95% confidence interval (CI): 1.22-3.18) and 2.56 (95%CI: 1.13-5.78), respectively. During the mean follow-up period of 29 months, the adjusted hazard ratios for death of successful compared with unsuccessful PCI were 1.0 (reference) compared with 2.04 (95%CI: 0.87-4.81) in the highest GFR group, 1.51 (95%CI: 1.11-2.06) compared with 2.07 (95%CI: 1.19-3.62) in the intermediate GFR group, and 2.69 (95%CI: 1.72-4.22) compared with 10.07 (95%CI: 4.91-20.5) in the lowest GFR group. CONCLUSIONS: Decreased GFR was associated with the risk of unsuccessful primary PCI. Moreover, unsuccessful PCI was associated with strikingly poor long-term survival in patients with GFR <30 ml .min(-1) . 1.73 m(-2). Steady success is essential when using PCI for such a high-risk population.


Subject(s)
Angioplasty, Balloon, Coronary , Glomerular Filtration Rate , Myocardial Infarction/mortality , Myocardial Infarction/physiopathology , Registries , Renal Insufficiency/mortality , Renal Insufficiency/physiopathology , Acute Disease , Aged , Aged, 80 and over , Asian People , Female , Follow-Up Studies , Humans , Japan , Male , Middle Aged , Myocardial Infarction/complications , Predictive Value of Tests , Prospective Studies , Renal Insufficiency/etiology , Risk Assessment , Risk Factors , Survival Rate
12.
Int J Cardiovasc Imaging ; 24(2): 201-10, 2008 Feb.
Article in English | MEDLINE | ID: mdl-17564812

ABSTRACT

OBJECTIVES: Multislice computed tomography (MSCT) has been currently utilized as a non-invasive diagnostic modality to detect coronary artery disease. We sought to investigate whether preprocedural lesion assessment by MSCT could offer strategic guidance in the setting of elective complex percutaneous coronary intervention (PCI). METHODS AND RESULTS: Twenty-six complex coronary artery lesions in 23 patients were evaluated using 16-row MSCT scanner and an off-line image analysis workstation prior to the PCI. Procedural strategies of PCI were planned based on the morphologic and geometric analysis of the target lesion and vessel. MSCT provided valuable strategic information, which was useful for subsequent PCI procedure. The three-dimensional computed tomography (CT) images allowed us to determine optimal working view angle that best demonstrated the target lesion with least foreshortening. Furthermore, the thin-slab maximum intensity projected CT images of the target lesion served as a preprocedural road map depicting the bends of complex luminal path, vessel geometry and occluded segment of the vessel. As results, procedural success was achieved in all cases with complex lesions including chronic total occlusion. CONCLUSIONS: Our preliminary results showed that preprocedural lesion and vessel assessment by MSCT provided important additive strategic information that led to successful complex PCI procedures.


Subject(s)
Angioplasty, Balloon, Coronary , Coronary Artery Disease/diagnostic imaging , Coronary Artery Disease/therapy , Tomography, X-Ray Computed/methods , Aged , Coronary Angiography , Female , Fluoroscopy , Humans , Imaging, Three-Dimensional , Male , Patient Care Planning , Radiographic Image Interpretation, Computer-Assisted
13.
Heart Vessels ; 22(4): 229-36, 2007 Jul.
Article in English | MEDLINE | ID: mdl-17653516

ABSTRACT

Recent studies have shown that circulating platelets play an important role in the development of restenosis early after coronary stent implantation. We investigated P-selectin expression and CD36 blockade on platelets by flow cytometry in 48 consecutive patients who underwent coronary stenting. P-selectin expression was significantly higher 1 day after stenting in patients who had restenosis (n = 15) than in those who had no restenosis (n = 28), and the odds ratio for restenosis in patients with high P-selectin levels (MFI > 6.5) was 11.67 (P < 0.001) as compared with patients who had intermediate and low P-selectin levels. CD36 blockade was assessed with the use of two anti-CD36 antibodies, OKM5 and GS95 (our new anti-CD36 antibody), the binding of which indicates total CD36 amount and free CD36 unoccupied by lipid-related ligands, respectively. Binding of OKM5 to platelets was similar before and after stenting in both groups. CD36 blockade on platelets was seen 1 day after stenting in the non-restenosis group, and the odds ratio for restenosis in patients without CD36 blockade [GS95 binding ratio >0.8 as compared with binding before stenting] on day 1 was 28.60 (P < 0.001). P-selectin expression and unoccupied CD36 on platelets shortly after stenting may be strong predictors of post-stent restenosis.


Subject(s)
Angioplasty, Balloon, Coronary , Blood Platelets/metabolism , CD36 Antigens/blood , Coronary Artery Disease/blood , Coronary Restenosis/blood , P-Selectin/blood , Stents , Aged , Binding, Competitive/physiology , Coronary Angiography , Coronary Artery Disease/therapy , Coronary Restenosis/diagnosis , Female , Flow Cytometry , Humans , Male , Middle Aged , Odds Ratio , Predictive Value of Tests
14.
Heart Vessels ; 22(3): 139-45, 2007 May.
Article in English | MEDLINE | ID: mdl-17533516

ABSTRACT

Objective evaluation of the functional significance of individual stenosis in patients with multiple lesions is crucial when performing percutaneous coronary intervention (PCI). Here we propose a novel lesion-specific parameter, the epicardial resistance index (ERI), which is derived from intracoronary pressure measurements, and validate its clinical usefulness. The ERI is defined as the ratio of the resistance of an epicardial coronary stenosis to that of downstream myocardium. After obtaining intracoronary pressure data by pull-back of a 0.014'' pressure wire, the ERI was calculated as the trans-lesional pressure gradient divided by (Pd-Pv) at maximum hyperemia, where Pd = the mean distal coronary pressure in the absence of any stenosis and Pv = the central venous pressure. Using 170 measurements obtained from 75 patients, the correlation of ERI with parameters obtained from quantitative coronary angiography (QCA) and intravascular ultrasound (IVUS) was studied. ERI showed a significant correlation with the QCA-derived percent diameter stenosis (r = 0.67, P < 0.001), and with the IVUS-derived minimum luminal area (r = 0.68, P < 0.001). In 55 patients who underwent PCI with bare metal stents, a postprocedural target lesion ERI value greater than 0.16 strongly predicted the need for subsequent revascularization within six months (81% sensitivity and 80% specificity). The ERI is a useful pressure-derived hemodynamic parameter that correlates with anatomical parameters. In addition, the postprocedural resistance of the target lesion indicated by the ERI is a reliable predictor of the late outcome of PCI.


Subject(s)
Coronary Stenosis/physiopathology , Coronary Stenosis/surgery , Severity of Illness Index , Vascular Resistance/physiology , Coronary Angiography , Coronary Restenosis/diagnostic imaging , Coronary Restenosis/physiopathology , Coronary Stenosis/diagnostic imaging , Female , Humans , Male , Middle Aged , Myocardial Revascularization/methods , Predictive Value of Tests , Pressure , ROC Curve , Regression Analysis , Sensitivity and Specificity , Stents , Ultrasonography, Interventional
15.
Heart Vessels ; 22(3): 152-7, 2007 May.
Article in English | MEDLINE | ID: mdl-17533518

ABSTRACT

Optimal stenting frequently requires additional stent post-dilatation following initial stent deployment. Stent post-dilatation using a focal expanding balloon (FB) that grows 0.5 mm larger centrally may achieve a larger final stent lumen with fewer stent edge injuries as compared to use of a conventional unidiameter balloon (UB). In the present prospective study, of 128 stented lesions in 122 patients, 63 lesions had stents dilated with FB (Group F), while 65 lesions had stents dilated with UB (Group U). All balloons for stent post-dilatation were half-sized up to reference diameter by on-line quantitative coronary analysis. There were no differences in the reference diameter, pre-procedural minimal lumen diameter (MLD), balloon/artery ratio, and final balloon pressure between the two groups. Post-procedural MLD in Group F was significantly larger than that in Group U (3.03 +/- 0.43 vs 2.80 +/- 0.47 mm, P < 0.001). Stent edge injury occurred in 4 patients, and stent thrombosis in 2 patients in Group U, but not in Group F. Minimal lumen diameter at 6 months in Group F was significantly larger than that in Group U (2.05 +/- 0.63 vs 1.82 +/- 0.66 mm, P < 0.05), and incidence of restenosis was significantly lower in Group F than Group U (9% vs 22%, P < 0.05). By using a focal expanding balloon for stent optimization, a larger stent lumen can be obtained safely, and subsequent incidence of restenosis can be reduced.


Subject(s)
Catheterization/methods , Coronary Stenosis/surgery , Stents , Chi-Square Distribution , Coronary Angiography , Coronary Restenosis/prevention & control , Female , Humans , Male , Middle Aged , Treatment Outcome
16.
Am J Cardiol ; 99(1): 26-30, 2007 Jan 01.
Article in English | MEDLINE | ID: mdl-17196456

ABSTRACT

There has been growing evidence associating obstructive sleep apnea (OSA) with cardiovascular pathogenesis. We hypothesized that OSA may affect outcomes after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS). We performed a sleep study in 89 consecutive patients with ACS who were successfully treated with PCI. Patients with an apnea hypopnea index > or =10/hour were considered to have OSA. Co-morbidity of OSA with ACS was found in 51 patients (57%). There were no differences in baseline demographics between patients with and without OSA, except for significantly higher high-sensitivity C-reactive protein levels (0.59 +/- 0.75 vs 0.29 +/- 0.20 mg/dl, p = 0.019) in patients with OSA. Patients were followed for a mean period of 227 days. The incidence of major adverse cardiac events (cardiac death, reinfarction, and target vessel revascularization) was significantly higher in patients with OSA (23.5% vs 5.3%, p = 0.022). By multivariate analysis, the presence of OSA was an independent predictor for major adverse cardiac events (hazard ratio 11.61, 95% confidence interval 2.17 to 62.24, p = 0.004). In addition, quantitative coronary angiography at 6-month follow-up depicted significantly greater late loss (1.28 +/- 0.84 vs 0.69 +/- 0.81 mm, p = 0.003) and a higher binary restenosis rate (36.5% vs 15.4%, p = 0.026) in patients with OSA compared with those without OSA. In conclusion, the present study showed a high prevalence of OSA among patients with ACS. Moreover, OSA appeared to be an independent predictor for clinical and angiographic outcomes after PCI.


Subject(s)
Angioplasty, Balloon, Coronary , Myocardial Infarction/mortality , Myocardial Infarction/therapy , Sleep Apnea, Obstructive/complications , Aged , Comorbidity , Coronary Angiography , Disease-Free Survival , Female , Humans , Japan/epidemiology , Male , Middle Aged , Multivariate Analysis , Myocardial Infarction/complications , Myocardial Infarction/diagnostic imaging , Myocardial Infarction/pathology , Prevalence , Risk Factors , Severity of Illness Index , Sleep Apnea, Obstructive/epidemiology
17.
Heart Vessels ; 21(5): 298-301, 2006 Sep.
Article in English | MEDLINE | ID: mdl-17151817

ABSTRACT

HMG-CoA reductase inhibitors (statins) have been shown to improve the endothelial function by lowering lipids. Recent studies also suggest a direct impact of statins on the vascular wall. We assessed the rapid effect of cerivastatin on the coronary flow velocity reserve (CFVR) using transthoracic Doppler echocardiography (TTDE). The coronary flow velocity from the distal left anterior descending artery was measured in 16 healthy subjects (all male, age 24-38 years) using a 5-MHz transducer, on the day before, just before, and 3 h after administering 0.3 mg of cerivastatin. Hyperemia was achieved by the intravenous administration of adenosine, and the CFVR was calculated as the radio of the mean diastolic hyperemic coronary flow velocity to the basal flow velocity. The serum lipid profile and high-sensitivity C-reactive protein (hsCRP) were measured. The CFVR following the single administration of cerivastatin increased from 2.93+/-0.58 to 3.91+/-0.86, P=0.003, and was significantly higher than the CFVR measured at the same time on the previous day (3.91+/-0.86 vs 3.37+/-0.48, P=0.009). Neither the serum lipid profile nor hsCRP exhibited a remarkable change after cerivastatin administration. We concluded that a single-dose administration of cerivastatin, an HMG-CoA reductase inhibitor, improves the coronary flow velocity reserve without modifying the serum lipid profile.


Subject(s)
Coronary Circulation/drug effects , Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage , Pyridines/administration & dosage , Adult , Analysis of Variance , Biomarkers/blood , Blood Flow Velocity/drug effects , Blood Flow Velocity/physiology , Coronary Circulation/physiology , Coronary Vessels/diagnostic imaging , Echocardiography , Humans , Male , Time Factors
18.
Nepal Med Coll J ; 8(2): 82-7, 2006 Jun.
Article in English | MEDLINE | ID: mdl-17017395

ABSTRACT

Vascular response after percutaneous coronary intervention (PCI) may differ in different ethnic group. Here we show the impact of peri-stent and intra-stent remodeling on coronary stenotic lesions in a group of Japanese patients. Those lesions were evaluated before, after and during follow up, with 3 dimensional intravascular ultrasound (IVUS) (3-D IVUS) and quantitative coronary angiography (QCA) 30 patients with pre, post and follow up IVUS were enrolled. Quantitative data are presented as the mean +/- SD, and categorical data as frequencies. Binary variables were compared with Mann Whitney's U test. There were 7 cases with restenosis (RS) and 23 cases with no-restenosis (NR). In QCA based evaluation, minimum lumen diameter (1.2 +/- 0.4 mm vs. 2.4 +/- 0.6 mm, p < 0.001) and % diameter stenosis (59.1+/- 16.1 vs. 23.3 +/- 16.1, p < 0.001) were significantly reduced in RS at follow up. Acute gain was similar among both groups (RS; 2.1 +/- 0.6 mm vs. NS; 2.2 +/- 0.7 mm, p = 0.5), however, late loss was significantly increased in RS (2.1 +/- 0.8 vs. 0.8 +/- 0.5, p < 0.001). At 3-D IVUS based follow up, lumen volume index was significantly reduced in RS (3.6 +/- 0.8 mm3/mm vs. 6.9 +/- 0.8 mm3/mm, p < 0.01). There was higher intrastent plaque volume index in RS in comparison to NR (5.4 +/- 1.4 mm3/mm vs. 3.1+/- 1.1 mm3/mm, p < 0.05). Linear regression analysis showed a tendency for a significant inverse correlation between the percentage of delta peristent volume index and the percentage of delta intrastent volume index (R2 = 0.12, p = 0.054). The intrastent plaque growth is the major player in causing restenosis.


Subject(s)
Angioplasty, Balloon, Coronary/adverse effects , Coronary Restenosis/diagnostic imaging , Stents , Blood Vessel Prosthesis Implantation , Coronary Angiography , Female , Humans , Male , Middle Aged , Prospective Studies , Risk Assessment , Risk Factors , Time Factors , Ultrasonography
19.
J Cardiol ; 48(1): 9-16, 2006 Jul.
Article in Japanese | MEDLINE | ID: mdl-16886495

ABSTRACT

OBJECTIVES: The incidence of contrast-induced nephropathy (CIN) after coronary angiography and the prognostic value in patients with acute myocardial infarction remains to be determined. This study investigated the frequency, predictors of CIN, and the prognostic significance of CIN in acute myocardial infarction patients undergoing emergent coronary angiography. METHODS: This study included 132 consecutive acute myocardial infarction patients undergoing emergent coronary angiography within 24 hr after the onset between January 1999 and June 2001. The serum creatinine concentration was measured on admission and at 48 hr after contrast medium exposure. CIN was defined as an increase in serum creatinine from the baseline > or = 0.5 mg/dl or > or = 25% at 48 hr after emergent coronary angiography. The patient characteristics, and in-hospital and long-term mortality were compared between the CIN and non-CIN groups. RESULTS: CIN occurred in 15 patients (11.4%) after emergent coronary angiography. The predictor of CIN development was preexisting renal impairment (serum creatinine concentration > or = 1.2 mg/dl on presentation; 21.9% vs 8.0%, odds ratio 3.22, 95% confidence interval 1.07-9.74, p = 0.04). In-hospital mortality was significantly higher in the CIN group than in the non-CIN group (13.3% vs 1.7%; odds ratio 8.85, 95% confidence interval 1.15-68.2, p = 0.01). The long-term mortality (mean follow-up period of 40 months) was also higher in the CIN group (26.7% vs 8.6%; hazard ratio 3.91, 95% confidence interval 1.21-12.5, p = 0.02). CONCLUSIONS: CIN was an independent predictor of both in-hospital and long-term mortality in acute myocardial infarction patients undergoing emergent coronary angiography. Preexisting renal insufficiency was associated with subsequent CIN.


Subject(s)
Contrast Media/adverse effects , Coronary Angiography/adverse effects , Iopamidol/adverse effects , Kidney Diseases/chemically induced , Myocardial Infarction/diagnostic imaging , Aged , Creatinine/blood , Emergencies , Female , Hospital Mortality , Humans , Male , Middle Aged , Myocardial Infarction/mortality , Predictive Value of Tests , Prognosis
20.
J Cardiol ; 47(4): 173-9, 2006 Apr.
Article in Japanese | MEDLINE | ID: mdl-16637251

ABSTRACT

OBJECTIVES: The prognosis of unstable angina pectoris may be more accurately predicted by the combination of C-reactive protein (CRP), which is a known inflammation marker, and troponin T (TnT), which is used for risk assessment for the prognosis of acute coronary syndrome. The present study investigated the correlations between pathophysiology and prognosis of severe unstable angina pectoris and CRP and TnT levels. METHODS: The correlation between CRP at admission and the prognosis was studied in 367 patients with severe unstable angina pectoris (Braunwald type II and III) who were admitted to our hospital between January 1998 and December 2000. The in-hospital and long-term prognosis was investigated in TnT-positive patients. In-hospital cardiac events were defined as death, myocardial infarction, heart failure and angina attacks during hospitalization. Long-term cardiac events were defined as death, myocardial infarction, heart failure and recurrence of angina. RESULTS: The incidence of in-hospital cardiac events in all patients was 30.2%. The CRP levels were higher in patients with cardiac events (0.97 +/- 2.67 vs 0.53 +/- 1.29 mg/d/, p = 0.057), but there was no significant difference between the two groups. The incidence of long-term cardiac events was 26.8%. The mean CRP level was significantly higher in patients with cardiac events than in patients without cardiac events (1.17 +/- 1.86 vs 0.43 +/- 1.14 mg/dl, p = 0.098). In TnT-positive patients (TnT > 0.1 ng/ml, 23% of all patients), the incidence of in-hospital cardiac events was 47.6% (p < 0.0001), significantly higher than that in all patients. TnT-positive patients with CRP levels of 0.5 mg/dl or higher (8% of all patients) had a markedly higher incidence of in-hospital cardiac events of 56.7% (p = 0.001) and long-term cardiac events of 46.7% (p = 0.01). CONCLUSIONS: CRP levels were useful in prediction of the long-term prognosis. TnT levels were useful in prediction of in-hospital prognosis. The present study suggested the possibility that the combined use of these biological markers could predict the prognosis of patients with unstable angina at early stage and more accurately.


Subject(s)
Angina, Unstable/diagnosis , C-Reactive Protein/analysis , Myocardial Infarction/diagnosis , Troponin T/blood , Biomarkers/blood , Feasibility Studies , Humans , Male , Prognosis
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