ABSTRACT
Three groups of women (aged 20-40 years) exposed to different levels of dioxins were studied in Chapaevsk town: 15 women working at the chemical fertilizer plant where occupational exposure to dioxins is possible; 16 women without dioxins occupational exposure, but living as far as 1-3 km from the plant; 14 women without dioxins occupational exposure and living as far as 5-8 km from the plant. No personal correlation related to dioxins exposure was found by chromosome aberrations (CA) in peripheral blood lymphocytes, micronuclei (MN) and nuclear anomalies in buccal mucosa cells. There were no significant differences between the groups in CA and MN. Karyopyknosis and karyorrhexis were significantly increased in the highest exposed group.
Subject(s)
Chromosome Aberrations , Dioxins/adverse effects , Occupational Exposure , Adult , Environmental Exposure , Female , Fertilizers , Humans , Industry , Mouth MucosaABSTRACT
A biomonitoring system is proposed, which involves measurement of environmental genetoxicants, determination of mutagenic accumulation in biological substrates of human beings and the severity of genetic abnormalities in their somatic cells. The toxicogenetical monitoring system includes the assessment of the examinees mental status. The results of application of the system are given by using as an example two Yaroslavl (machine-building and oil-processing) plants.
Subject(s)
Carcinogens/adverse effects , Environmental Monitoring/methods , Mutagenesis/drug effects , Mutagens/adverse effects , Neoplasms, Experimental/chemically induced , Occupational Exposure/adverse effects , Adult , Animals , Carcinogens/analysis , DNA, Neoplasm/drug effects , DNA, Neoplasm/genetics , Humans , Male , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Middle Aged , Mutagens/analysis , Neoplasms, Experimental/genetics , Neoplasms, Experimental/metabolism , Retrospective StudiesABSTRACT
The paper presents the monitoring results of the genetic and mental status of workers from 2 plants of Yaroslavl. The groups of the examinees were formed in terms of unhealthy working conditions and residence in clean or polluted areas of the city. The individuals working under harmful and living under unfavourable environmental conditions were found to be more commonly acute or chronically stressed or fatigable than the control workers. Those under stress were shown to be more responsive to environmental genetic toxic agents. Whether psychological training may be used to form groups at high genetic risk is discussed.
