Subject(s)
Actihaemyl/therapeutic use , Lichen Planus, Oral/drug therapy , Wound Healing/drug effects , Adult , Aged , Aged, 80 and over , Biopsy , Combined Modality Therapy , Drug Evaluation , Drug Therapy, Combination , Female , Gels , Humans , Lichen Planus, Oral/pathology , Male , Middle Aged , Mouth Mucosa/drug effects , Mouth Mucosa/pathology , OintmentsSubject(s)
Keloid/therapy , Adolescent , Adult , Child , Child, Preschool , Combined Modality Therapy , Cryosurgery , Humans , Microwaves/therapeutic useABSTRACT
The results of clinical and morphological analysis of two observations of the erythrodermic form of mycosis fungoides and Sezary's syndrome confirmed the opinion that Sezary's syndrome was a leukemic variant of mycosis fungoides. Morphological differences between atypical lymphocytes (Sezary's cells) and activated forms of lymphocytes are emphasized.
Subject(s)
Leukocytes/pathology , Sezary Syndrome/pathology , Skin/pathology , Adult , Biopsy , Female , Humans , Male , Microscopy, Electron , Middle Aged , Sezary Syndrome/bloodSubject(s)
Photochemotherapy , Psoriasis/pathology , Skin/pathology , Adult , Biopsy , Female , Histocytochemistry , Humans , Male , Middle Aged , Psoriasis/drug therapy , Time FactorsABSTRACT
Histological and electron microscopic examinations of cellular infiltration were carried out in squamous cell carcinoma of the skin in humans, in the zone of dinitrochlorobenzene allergic contact dermatitis in guinea pigs, and in allotransplant and the surrounding skin in mice. In all the processes studied, the epithelial part of the cell infiltration area was found to differ from the connective tissue area by cell composition. The epithelial sheets were shown to be infiltrated mostly with heterogenous lymphocytes as well as occasional macrophages forming simple and slit-like contacts with epithelial cells. It is doubtful whether lymphocyte-macrophage infiltration of the epithelium causes necrobiotic changes in its cells in the processes studied.
Subject(s)
Carcinoma, Squamous Cell/ultrastructure , Dermatitis, Contact/pathology , Monocytes/ultrastructure , Skin Neoplasms/ultrastructure , Skin Transplantation , Animals , Epithelium/ultrastructure , Graft Rejection , Guinea Pigs , Humans , Hypersensitivity, Delayed/pathology , Mice , Microscopy, Electron , Skin/ultrastructureSubject(s)
Epidermis/ultrastructure , Keratins/biosynthesis , Psoriasis/pathology , Adult , Child , Epidermis/metabolism , Humans , Microscopy, Electron , Psoriasis/metabolismABSTRACT
Histological and electron microscopic examination of changes in the skin and blood revealed three different stages in the development of experimental allergic contact dermatitis (ACD). The primary contact reaction (24 hours) had features of nonspecific inflammation with some morphological signs of initial sensitization. Inflammation in the flare-up reaction (5-7 days) is the result of the immune process, and basophilic infiltration of the skin is the obligatory component of this reaction. ACD (patch test at 15 days) was shown to have morphological manifestations typical of the delayed type hypersensitivity and some signs of the immediate type reactions.
