ABSTRACT
Clinicomorphological characteristics of glomerulonephritis in infectious endocarditis (IEGN) were studied in 62 patients (with samples of autopsy material being used in 52 instances). IEGN presents with dissaminated and focal proliferative alterations involving extracapillary and/or tubulointerstitial components, and is characterized by a broad variability of indices for proteinuria, hematuria and cylindruria. In diffuse prolipherative glomerulonephritis the degree of proteinuria and cylindruria appear to be significantly higher than in focal segmental proliferative glomerulonephritis, as is the incidence rate of development of renal insufficiency and its gravity.
Subject(s)
Endocarditis, Bacterial/pathology , Glomerulonephritis/pathology , Adolescent , Adult , Aged , Endocarditis, Bacterial/complications , Endocarditis, Bacterial/diagnosis , Female , Glomerulonephritis/diagnosis , Glomerulonephritis/etiology , Humans , Kidney/pathology , Male , Middle Aged , Prospective Studies , Renal Insufficiency/diagnosis , Renal Insufficiency/etiology , Renal Insufficiency/pathology , Retrospective StudiesABSTRACT
Prognostic significance of various clinical and laboratory indices for predicting the course and outcome of infectious endocarditis (IE) has been analyzed for 139 IE patients aged 15-68 (77 males and 62 females). The unfavourable prognosis was associated with uncontrollable sepsis, persistence of circulating immune complexes and developing glomerulonephritis. The latter had also prognostic signs unfavourable for IE: moderate or severe proteinuria and/or cylindruria, reduced renal function, diffuse proliferation, pronounced extracapillary and/or tubulointerstitial components.
Subject(s)
Endocarditis, Bacterial/diagnosis , Adolescent , Adult , Aged , Cause of Death , Endocarditis, Bacterial/mortality , Endocarditis, Bacterial/pathology , Female , Humans , Male , Middle Aged , Prognosis , Prospective StudiesABSTRACT
The study of urinary sediment is essential in laboratory diagnosis. Conventional clinical methods are now used in line with computer-aided techniques and additional microscopy of the sediment elements. The paper provides a brief analysis of clinical situations characterized by appearance in the urine of abnormal numbers of leukocytes, erythrocytes, casts; provides clinical assessment of additional microscopic methods able to accentuate qualitative characteristics of the urinary syndrome; considers possibilities of application of the urinary sediment data in follow-up to improve diagnosis and control on-going treatment.
