[Condition of erythrocytes in intact and vagotomized rats of various age after massive hemorrhage].

Sharp massive hemorrhage (30-35 % of total amount of blood) in rats are accompanied by natural changes of morpho-functional characteristics of erythrocytes: diameter, the area, polarization, the factor of the form, integrated and specific optical density. Thus, in certain terms, after hemorrhage at young initially intact animals average diameter, the area, integrated optical density actually increase as well as the value of polarization and the factor of the form of erythrocytes growth. In vagotomized rats of the same age group, in reply to hemorrhage, the increase in value of the factor of the form only is obvious. In initially intact old animals in these conditions, an increase of integrated and specific optical density and of the factor of the form also takes place. In old vagotomized rats, the average diameter and the erythrocyte area accrue. Thus, the character and dynamics of response of erythrone in initially intact and vagotomized (through 14 days after operation) animals essentially differ and have certain features dependent on age. Thus, in young initially intact rats, the most expressed changes are marked in 3-10 hours whereas in vagotomized animals of the same age group - in 3 and 96 hours after hemorrhage. In old initially intact rats, the greatest deviations of the investigated parameters are observed in 3 and 96 hours, in the vagotomized animals - in 3 and 24 hours.

[Use of antihypoxants and antioxidants for pharmaco-correction of disorders of water metabolism in the liver and small intestine after vagotomy]. / Primenenie antigipoksantov i antioksidantov dlia farmakokorrektsii narushenii metabolizma vody v pecheni i tonkoi kishke posle vagotomii.

Bilateral subdiaphragmatic vagotomy in rats leads to hepatic and small intestinal water metabolic disorders appeared as higher levels of total water, longer spin-grid (T1) and spin-spin (T2) relaxation and impaired correlation between T1 and T2. The time course of changes in water metabolism in the liver is one-sided (maximum after 7 days) at the same time in the small intestine is two-sided (maximum after 7 and 30 days). The antihypoxant tomerzole and the antioxidant dibunol produce a partial normalizing effect on water metabolism in the studied viscera of the animals vagotomized (at day 30), the highest efficiency was demonstrated by dibunol whose pharmacological activity is the greatest in the small intestine.