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Biomed Khim ; 60(1): 115-24, 2014.
Article in Russian | MEDLINE | ID: mdl-24749252

ABSTRACT

The effects of the small doses of the preparation Gistochrome, containing natural polyhydroxynaphtoquinoine echinochrom A from flat sea urchin Scaphechinus mirabilis, on blood biochemical parameters have been studied in patients with cardiovascular diseases. Gistochrome administration influenced the LPO-antioxidant protection system, indicating reinforcement of antioxidant protection mechanisms. Gistochrome modulated the immune status and the plasma cytokine profile. Thus, Gistochrome may be recommended as means of additional therapy for patients with cardiovascular diseases for correcting the metabolic, immunological and redox impairments.


Subject(s)
Antioxidants/therapeutic use , Atherosclerosis/blood , Hypertension/blood , Immunologic Factors/therapeutic use , Myocardial Ischemia/blood , Naphthoquinones/therapeutic use , Animals , Antigens, CD/metabolism , Antioxidants/isolation & purification , Atherosclerosis/drug therapy , Atherosclerosis/physiopathology , Blood Cell Count , Case-Control Studies , Cholesterol, HDL/blood , Cholesterol, LDL/blood , Cholesterol, VLDL/blood , Cytokines/metabolism , Humans , Hypertension/drug therapy , Hypertension/physiopathology , Immunologic Factors/isolation & purification , Injections, Intramuscular , Lipid Peroxidation/drug effects , Malondialdehyde/blood , Middle Aged , Myocardial Ischemia/drug therapy , Myocardial Ischemia/physiopathology , Naphthoquinones/isolation & purification , Oxidation-Reduction/drug effects , Sea Urchins/chemistry , Triglycerides/blood
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