ABSTRACT
Boron neutron capture therapy (BNCT) can become an instrument for patients with malignant neoplasms of the rectum and colon. Here we evaluate the effectiveness of BNCT performed at the accelerator based epithermal neutron source at G. I. Budker Institute of Nuclear Physics, Siberian Division of Russian Academy of Sciences, in relation to subcutaneous xenografts of human colon adenocarcinoma SW-620 in SCID mice. Utilization of BNCT with boronоphenylalanine (BPA) and sodium borocaptate (BSH), which were injected intravenously into the retroorbital sinus, resulted in a significant decrease in tumor volumes compared to the control group (no radiation).
Subject(s)
Adenocarcinoma , Boron Neutron Capture Therapy , Brain Neoplasms , Colorectal Neoplasms , Adenocarcinoma/radiotherapy , Animals , Boron Neutron Capture Therapy/methods , Colorectal Neoplasms/radiotherapy , Heterografts , Humans , Mice , Mice, SCID , Sulfhydryl CompoundsABSTRACT
Optical quality GaSe crystals have been grown by vertical Bridgman method. The structural properties and micromorphology of a cleaved GaSe(001) surface have been evaluated by RHEED, SEM and AFM. The cleaved GaSe(001) is atomically flat with as low roughness as â¼0.06 nm excepting local hillock type defects. The hillock-type formations are round-shaped with a bottom diameter of â¼200 nm and a height of â¼20-35 nm. The drastic depletion of the hillock material by gallium has been indicated by EDX measurements.
