1.
Zhongguo Yao Li Xue Bao
; 11(5): 457-9, 1990 Sep.
Article
in Chinese
| MEDLINE
| ID: mdl-2130604
ABSTRACT
Clonidine 2 mg/kg ig inhibited the rat gastric ulcers induced by pyloric ligation, stress and indomethacin by 71%, 77% and 82%, respectively. Clonidine 2 mg/kg ig tended to accelerate the healing of gastric ulcer induced by acetic acid, and the healing rate was 61%. Clonidine decreased the secretion of gastric acid and pepsin, and increased the release of gastric barrier mucus. These actions may contribute to its protective effect against ulceration.