ABSTRACT
Three stable and simple synthetic routes of labeled D9 -Mabuterol, D9 -Bambuterol, and D9 -Cimbuterol were described with 98.5%, 99.7%, and 98.4% isotopic abundance and good purity. These structures and isotope-abundance were confirmed according to 1 H NMR and liquid chromatography-tandem mass spectrometry.
Subject(s)
2-Hydroxyphenethylamine/analogs & derivatives , Aniline Compounds/chemistry , Aniline Compounds/chemical synthesis , Clenbuterol/analogs & derivatives , Deuterium/chemistry , Terbutaline/analogs & derivatives , 2-Hydroxyphenethylamine/chemical synthesis , 2-Hydroxyphenethylamine/chemistry , Chemistry Techniques, Synthetic , Clenbuterol/chemical synthesis , Clenbuterol/chemistry , Isotope Labeling , Terbutaline/chemical synthesis , Terbutaline/chemistryABSTRACT
Ruthenium-catalyzed oxidation of multisubstituted allyl alcohols in the presence of benzaldehyde gives enals or enones in good yields. Unlike the commonly reported ruthenium-catalyzed isomerization reaction of allyl alcohols to give saturated ketones, an intermolecular rather than intramolecular hydrogen transfer is involved in this transformation. This reaction offers an efficient, mild, and high-yielding method for the preparation of substituted α,ß-unsaturated compounds.
