American college of radiology ovarian-adnexal reporting and data system ultrasound (O-RADS): Diagnostic performance and inter-reviewer agreement for ovarian masses in children.

Objective: To evaluate the diagnostic performance and inter-observer agreement of the American College of Radiology Ovarian-Adnexal Reporting and Data System Ultrasound (O-RADS) in the diagnosis of ovarian masses in children. Methods: From June 2012 to December 2021, 163 ovarian masses in 159 patients with pathologic results were retrospectively analyzed. Each mass was classified into an O-RADS category according to the criteria. The diagnostic performance of O-RADS for detecting malignant ovarian masses was assessed using histopathology as the reference standard. Kappa (k) statistic was used to assess inter-observer agreement between a less-experienced and a well-experienced radiologist. Results: Out of 163 ovarian masses, 18 (11.0%) were malignant and 145 (89.0%) were benign. The malignancy rates of O-RADS 5, O-RADS 4, and O-RADS 3 masses were 72.7%, 34.6%, and 4.8%, respectively. The area under the receiver operating characteristic curve was 0.944 (95% CI, 0.908-0.981). The optimal cutoff value for predicting malignant ovarian masses was > O-RADS 3 with a sensitivity, specificity, and accuracy of 94.4%, 86.2% and 86.2% respectively. The inter-observer agreement of the O-RADS category was good (k = 0.777). Conclusions: O-RADS has a high diagnostic performance for children with ovarian masses. It provides an effective malignant risk classification for ovarian masses in children, which shows high consistency between radiologists with different levels of experience.

Social exploration: When people deviate from options explored by others.

People often face choices between known options and unknown ones. Our research documents a social-exploration effect: People are more likely to explore unknown options when they learn about known options from other people's experiences. Across four studies (N = 2,333), we used an incentive-compatible paradigm where participants chose between known and unknown options (e.g., cash bonuses). We found higher exploration rates (i.e., choosing of unknown options) when information about known options came from other people, compared with an unidentified source (Study 1a) or a computer (Studies 1b-4). We theorize that the social-exploration effect results from people's tendency to intuitively adopt a group-level perspective with other people: a "we"-perspective. Thus, in social contexts, people explore more to diversify their experience as a group. Supporting this account, we find the effect attenuates in exploration of losses, where people do not wish to adopt a group-level perspective of others' losses (Study 2). Furthermore, the effect is obtained only if others have experienced the outcome; not when they only revealed its content (Study 3). Finally, the social-exploration effect generalizes to everyday choices, such as choosing a movie to watch (Study 4). Taken together, these findings highlight the social aspect of individual exploration decisions and offer practical implications for how to encourage exploration. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

A case of polycystic ovary syndrome with inevitable miscarriage and multi-site venous thrombosis caused by hereditary protein C deficiency.

BACKGROUND: Polycystic ovarian syndrome (PCOS) affects up to 18% of reproductive-aged women and raises the risk of venous thromboembolic disease (VTE), due to metabolic features and an apparent fibrinolytic state. Recent studies have shown an increased risk of VTE (1.5- to 2-fold) in patients with PCOS as compared to those without PCOS. Mutations in the Protein C (PC) gene (PROC) lead to deficiency or dysfunction of the protein, Protein C deficiency is the main clotting physiological inhibitor of protein C cofactors, and is a risk factor for venous thrombosis, which can cause a variety of events, including miscarriage. This case report proposes a correlation between PCOS, protein C deficiency, venous thrombosis and inevitable miscarriage. CASE PRESENTATION: A 33-year-old Chinese woman was diagnosed with Polycystic Ovary Syndrome (PCOS) in 2015. During the course of treatment, she took ethinylestradiol and cyproterone acetate tablets for more than one year. In 2016, she was sent to a hospital for emergency care due to explosive thrombosis (thrombosis in multiple parts of the body and pulmonary thrombosis). In 2020, the patient became pregnant via natural means and came to our hospital for treatment. During the second trimester, she experienced an inevitable miscarriage. High-throughput sequencing (NGS) of peripheral blood lymphocytes revealed that the patient had a protein C deficiency resulting from a heterozygous mutation deletion of 572_574 in exon 7. CONCLUSION: PC deficiency in conjunction with PCOS and the concomitant use of oral contraceptive (COC) would increase the risk of VTE, especially in the early stages of COC use.

Words speak louder: conforming to preferences more than actions.

Whereas people generally conform to others' choices, this research documents that conformity decreases once others have acted on their chosen options. It suggests words speak louder than actions-people are more likely to conform to others' preferences than their actions. Specifically, people are less likely to follow another person's food choice if that person has already eaten his or her selected food (Study 1), and are less likely to follow others' choices of household items if these choices are framed in terms of action (others "want to have it") rather than preference (others "like it"; Study 2). People's tendency to mentally share others' actions causes the decrease in conformity. Indeed, people recall greater past consumption of items that others have had (Study 3), choose differently only when they can complement (vs. contradict) what others have (Study 4), and are more strongly affected by the choices of those close to them (vs. strangers; Study 5). Finally, even when information about others' actions and preferences are simultaneously available (e.g., in online shopping and the consumption of social media), people are more likely to follow what others prefer, rather than what others have (Study 6).

Approach aversion: negative hedonic reactions toward approaching stimuli.

We live in a dynamic world, surrounded by moving stimuli-moving people, moving objects, and moving events. The current research proposes and finds an approach aversion effect-individuals feel less positively (or more negatively) about a stimulus if they perceive it to be approaching rather than receding or static. The effect appears general, occurring whether the stimulus is initially negative or nonnegative and whether it moves in space (toward or away from "here"), in time (toward or away from "now"), or in probability (toward or away from "sure"). This research complements extensive existing research on perceived static distance of stimuli (near vs. far) by exploring perceived dynamic movement of stimuli (approaching vs. receding), showing that the effect of movement is distinct from the effect of distance.