1.
QJM
; 105(10): 1011-6, 2012 Oct.
Article
in English
| MEDLINE
| ID: mdl-21893584
Subject(s)
Brain/pathology , Hemianopsia/etiology , Immune Reconstitution Inflammatory Syndrome , Immunosuppression Therapy/adverse effects , JC Virus/isolation & purification , Leukoencephalopathy, Progressive Multifocal , Polyomavirus Infections , Antimalarials/administration & dosage , Antiviral Agents/administration & dosage , Biopsy , Hemianopsia/diagnosis , Hemianopsia/physiopathology , Histamine H1 Antagonists/administration & dosage , Histological Techniques/methods , Humans , Immune Reconstitution Inflammatory Syndrome/diagnosis , Immune Reconstitution Inflammatory Syndrome/etiology , Immune Reconstitution Inflammatory Syndrome/physiopathology , Immune Reconstitution Inflammatory Syndrome/therapy , Immunocompromised Host , Immunosuppression Therapy/methods , Leukoencephalopathy, Progressive Multifocal/diagnosis , Leukoencephalopathy, Progressive Multifocal/drug therapy , Leukoencephalopathy, Progressive Multifocal/etiology , Leukoencephalopathy, Progressive Multifocal/physiopathology , Magnetic Resonance Imaging , Male , Mefloquine/administration & dosage , Mianserin/administration & dosage , Mianserin/analogs & derivatives , Middle Aged , Mirtazapine , Polyomavirus Infections/diagnosis , Polyomavirus Infections/drug therapy , Polyomavirus Infections/etiology , Polyomavirus Infections/physiopathology , Sarcoidosis/therapy , Treatment Outcome , Withholding Treatment
2.
Intern Med J
; 34(1-2): 66-9, 2004.
Article
in English
| MEDLINE
| ID: mdl-14748917
ABSTRACT
We studied the safety of autologous peripheral blood stem-cell transplantation (PBSCT) in four patients with progressive multiple sclerosis. Clinical and magnetic resonance imaging outcomes were secondary end-points. Cladribine administration preceded filgrastim-primed PBSC collection, aiming for lymphocyte depletion. Conditioning was with antithymocyte globulin and cyclophosphamide. The procedure was well tolerated, but without obvious clinical benefit. The study was terminated when other therapeutic options with lower morbidity became available.
