Trends in validity of central line-associated bloodstream infection surveillance data, New York State, 2007-2010.

BACKGROUND: In 2007, New York State (NYS) hospitals began mandatory public reporting of central line-associated bloodstream infection (CLABSI) data associated with intensive care units (ICUs) into the National Healthcare Safety Network (NHSN). Facilities were required to use the NHSN device-associated CLABSI criteria to identify laboratory-confirmed bloodstream infections. METHODS: Onsite audits were conducted in ICUs by NYS hospital-acquired infection program staff using a standardized database. Hospitals provided ICU patient medical records with a positive blood culture during a selected time frame. RESULTS: Between 2007 and 2010, an average of 79% of all reporting hospitals were audited annually. Of the 5,697 patients audited, 3,104 (54%) had a central line in place, and 650 of the patients with a central line (21%) were identified as having a CLABSI by the hospital-acquired infection program reviewer. Between 2007 and 2010, the specificity increased from 90% to 99%, whereas the sensitivity remained stable at approximately 71%. As a result of the audit process, the NYS 2010 CLABSI rate increased by 5.6%. CONCLUSIONS: A standardized audit process has helped improve the accuracy of CLABSI reporting. Data validation provides consistent data for measuring the progress of infection prevention strategies and allows for relevant comparison of ICU data.

Use of incubation time to detection in BACTEC 9240 to distinguish coagulase-negative staphylococcal contamination from infection in pediatric blood cultures.

BACKGROUND: Growth of coagulase-negative staphylococci (CoNS) in a blood culture indicates infection or contamination. Differentiation may be difficult in pediatric patients from whom only a single blood culture is commonly obtained. METHODS: We evaluated the use of the incubation time to detection of growth [time to positive (TTP)] of CoNS in a continuously monitored blood culture system (BACTEC Peds/F bottles in BACTEC 9240) to differentiate infection from contamination. Three groups of febrile pediatric patients with blood cultures growing CoNS were identified: Group 1, children with vascular catheter-associated bloodstream infection; Group 2, previously healthy children with a contaminant; Group 3, chronically ill children with a contaminant. RESULTS: The median TTP for blood cultures from the 17 infection episodes, 11 h [mean, 13.2 h; 95% confidence interval (CI), 11.4 to 17.7], was significantly shorter than either the 30 episodes in the previously healthy group with contaminant, median 19 h (mean, 22.7 h; 95% CI 19.5 to 26.2; P < 0.0001) or the 12 episodes in the chronically ill group with contaminant, median 24 h (mean, 35.2 h; 95% CI 17.2 to 53.1; P < 0.0001). A TTP of < or =15 h had a positive predictive value of 84% for diagnosis of infection. A TTP of > or =22 h had a positive predictive value of 87% for diagnosis of contaminant. CONCLUSION: In our experience the TTP was a useful adjunctive test to determine the clinical significance of isolation of CoNS from a blood culture from a pediatric patient.