Subject(s)
Accidents , Catheters, Indwelling/adverse effects , Kidney Failure, Chronic/therapy , Medical Errors , Peritoneal Dialysis, Continuous Ambulatory/adverse effects , Peritoneal Dialysis, Continuous Ambulatory/instrumentation , Urinary Bladder/injuries , Wounds and Injuries/etiology , Aged , Device Removal , Humans , Male , Radiography , Renal Dialysis , Ultrasonography , Urinary Bladder/diagnostic imaging , Urinary Bladder/surgery , Urinary Catheterization/instrumentation , Urinary Catheters , Wounds and Injuries/diagnosis , Wounds and Injuries/therapyABSTRACT
BACKGROUND AND AIM: Epidemiology of Helicobacter pylori infection has regional variation. Effect of eradication of H. pylori on symptoms of functional dyspepsia is uncertain, and the data in Asian scenario are scanty. The study aimed to see H. pylori positivity rate in patients of functional dyspepsia and the effect of its eradication on symptoms. METHODS: Randomized, double-blind, placebo-controlled study was the study design used. Patients of functional dyspepsia defined as per Rome 2 criteria were tested for H. pylori infection by rapid urease test and gastric biopsy. H. pylori-positive patients were randomly allocated to triple therapy (20 mg of omeprazole, 500 mg of clarithromycin, and 1000 mg of amoxicillin orally two times daily) and omeperazole plus identical placebo for 2 weeks. Symptoms were assessed with the weekly Likert scale. RESULTS: H. pylori positivity rate in functional dyspepsia was 1160/2000 (58%). At 6 weeks, the eradication rate for H. pylori in triple therapy and placebo group was (181/259 [69.8%] and 13/260 [5.0%], P = 0.001), respectively. On intention-to-treat analysis, the symptom resolution at 1 month was (157/259 [60.7%] and 136/260 [52.3%], P = 0.38), respectively. At 12 months, H. pylori eradication and healing of gastritis in triple therapy and placebo group were (116/174 [66.7%] and 12/180 [6.7%], P = 0.001) and (132/174 [75.9%] and 11/180 [6.1%], P = 0.001), respectively. On intension to treat, the resolution of symptoms in triple therapy and placebo group was (95/217 [43.7%] and 72/195 [36.9%], P = 0.13). CONCLUSION: There is high H. pylori positivity rate in patients of functional dyspepsia. The eradication of H. pylori does not resolve the symptoms despite healing of gastritis.
Subject(s)
Dyspepsia/epidemiology , Dyspepsia/physiopathology , Gastroenteritis/epidemiology , Gastroenteritis/microbiology , Helicobacter Infections , Helicobacter pylori , Adult , Aged , Double-Blind Method , Dyspepsia/etiology , Female , Gastroenteritis/complications , Gastroenteritis/drug therapy , Humans , India/epidemiology , Male , Middle Aged , Prevalence , Young AdultABSTRACT
Premature ovarian failure has an overall prevalence of 0.3% to 0.9% in general population. If fertility is a concern, treatment usually consists of estrogen therapy as hormone replacement and oocyte donation. Spontaneous pregnancy in affected women is uncommon. We report a case of a 34-year old woman, who had premature ovarian failure and primary hypothyroidism, and conceived spontaneously eleven years after the development of premature ovarian failure and correction of hypothyroidism.
Subject(s)
Hypothyroidism/drug therapy , Pregnancy Complications , Pregnancy Outcome , Primary Ovarian Insufficiency/drug therapy , Estrogen Replacement Therapy , Female , Humans , Hypothyroidism/diagnosis , Pregnancy , Primary Ovarian Insufficiency/diagnosis , Thyroxine/therapeutic useABSTRACT
Premature ovarian failure has an overall prevalence of 0.3 percent to 0.9 percent in general population. If fertility is a concern, treatment usually consists of estrogen therapy as hormone replacement and oocyte donation. Spontaneous pregnancy in affected women is uncommon. We report a case of a 34-year old woman, who had premature ovarian failure and primary hypothyroidism, and conceived spontaneously eleven years after the development of premature ovarian failure and correction of hypothyroidism.
A falência ovariana prematura tem uma prevalência global variando de 0,3 por cento a 0,9 por cento na população em geral. Nos casos em que existe preocupação com a fertilidade, o tratamento geralmente consiste de terapia de reposição hormonal com estrógeno e doação de oócitos. A gravidez espontânea em mulheres afetadas não é comum. Relatamos um caso de uma mulher de 34 anos de idade que apresentou falência ovariana prematura e hipotireoidismo primário e concebeu espontaneamente onze anos após o desenvolvimento da falência ovariana prematura e da correção do hipotireoidismo.
