Subject(s)
Air Pollutants/adverse effects , Allergens , Headache/etiology , Adult , Aged , Female , Humans , Male , SeasonsABSTRACT
This report reviews the results of prophylactic immunotherapy carried out on 105 ragweed hay fever patients treated for at least two years with an alum-precipitated pyridine ragweed (Allpyral) extracts prepared from equal parts of low and giant ragweed pollen. Good or excellent clinical results were obtained in most patients with a minimum of reaction, notably constitutional ones, even when the interval between injections was quite prolonged. Seasonal asthma rarely occurred in the treated patients. In the author's opinion, the advantages offered by these extracts, notably their relative safety and at least equal clinical effectiveness, seem to warrant their preference over similar aqueous ragweed extracts currently employed or over attempted modifications of aqueous extracts.
Subject(s)
Antigens/therapeutic use , Pollen , Rhinitis, Allergic, Seasonal/therapy , Adolescent , Adult , Antigens/adverse effects , Antigens, Dermatophagoides , Child , Child, Preschool , Dose-Response Relationship, Immunologic , Female , Humans , Male , Middle AgedABSTRACT
Excellent clinical results were obtained in 85 patients with chronic asthma who took corticosteroids (mostly triamcinolone) on a long-term basis for periods varying from one to 26 years. There was a minimum of side-effects, none serious; the most discomforting were ecchymosis and a tendency to easy bruising. The results of this and previous studies have convinced the author that corticosteroids, if judiciously used, are the most valuable adjunct we have in the treatment of acute and chronic asthma.
Subject(s)
Adrenal Cortex Hormones/adverse effects , Asthma/drug therapy , Acne Vulgaris/etiology , Beclomethasone/therapeutic use , Betamethasone/adverse effects , Body Weight , Dose-Response Relationship, Drug , Ecchymosis/etiology , Edema/etiology , Hirsutism/etiology , Humans , Prednisone/adverse effects , Triamcinolone/therapeutic useABSTRACT
In 18 ragweed hay fever patients who received injections of alum-precipitated pyridine (Allpyral) ragweed extracts in maintenance doses of between 6000 and 8000 P.N.U. at intervals of between two and four months over a two-year period, the prolonged interval did not seem to influence either the clinical response or the tendency to reaction, or result in significant change in immunological tolerance as determined by antibody studies, which included fluorescent antibody assays, as well as hemagglutination and RAST technics.
Subject(s)
Plant Extracts/therapeutic use , Pyridines/therapeutic use , Adult , Alum Compounds/therapeutic use , Antibody Formation , Chemical Precipitation , Dose-Response Relationship, Immunologic , Female , Fluorescent Antibody Technique , Hemagglutination Tests , Humans , Male , Middle Aged , Radioallergosorbent Test , Rhinitis, Allergic, Seasonal/drug therapy , Time FactorsSubject(s)
Hypersensitivity/history , Immunologic Techniques/history , Asthma/drug therapy , Asthma/etiology , Asthma/physiopathology , Chronic Disease , Drug Hypersensitivity , Education, Medical, Continuing , Food Hypersensitivity , History, 20th Century , Humans , Hypersensitivity/diagnosis , Hypersensitivity/physiopathology , Immunotherapy , Skin Tests/history , United StatesABSTRACT
Hyposensitization therapy with APP extracts was found to be effective in 80% of 185 patients allergic to animals (96 to cats, 84 to dogs and 5 to horses) with a minimum of reactions (2.5 local and 0.2% constitutional). Lower respiratory symptoms were the most common complaints, followed by nasal, ocular and respiratory, singly or in combination.
Subject(s)
Allergens/administration & dosage , Desensitization, Immunologic , Hair , Hypersensitivity/drug therapy , Pyridines , Adolescent , Adult , Alum Compounds , Animals , Cats , Dogs , Horses , Humans , Hypersensitivity/etiology , MaleABSTRACT
A rare instance of contact-type urticaria resulting from an acquired sensitization to cephalosporin compounds in a chemist is reported. Patch tests elicited an immediate urticarial rather than a delayed contact-type response. Similar control tests to other antibiotics gave negative results. Although the patient's primary complaint was urticaria, prolonged or excessive contact with the cephalosporins caused coryza and dyspnea. Following transfer to another laboratory where the patient worked with other chemicals, there was no recurrence of symptoms.
