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[Experimental basis fur using D-penicillamine in liver cirrhosis]. / Eksperimental'noe obosnovanie primeneniia D-penitsillamina pri tsirroze pecheni.

Nikolaev, A V; Tugarinova, V N; Zolotnitskaia, R P; Milovanova, Z P; Kotova, E N.

Biull Eksp Biol Med ; 91(3): 290-3, 1981 Mar.

Article in Russian | MEDLINE | ID: mdl-7248500

ABSTRACT

The therapeutic action of D-penicillamine (D-PA) in experimental liver cirrhosis was examined comprehensively and compared to that of prednisolone. D-RA primarily depressed fibrillogenesis, preventing the appearance of scar lesions in liver tissue. The drug exerted a beneficial effect on excretory and albumin-synthetizing function of the liver and had a protective action of oxidation function of liver mitochondria and the content of cytochromes. Unlike D-PA, prednisolone primarily reduced the manifestations of auto-immunization. The remainder of the tests have revealed no essential differences in the action of the drugs. The risk of prednisolone overdosage and side effects it produces have been recorded.

Subject(s)

Liver Cirrhosis, Experimental/drug therapy , Penicillamine/therapeutic use , Prednisolone/therapeutic use , Animals , Chinchilla , Liver/physiopathology , Liver/ultrastructure , Liver Cirrhosis, Experimental/pathology , Liver Cirrhosis, Experimental/physiopathology , Male , Microscopy, Electron , Rabbits

[Effect of D-penicillamine on the development and involution of experimental liver cirrhosis]. / Vliianie D-penitsillamina na razvitie i involiutsiiu éksperimental'nogo tsirroza pecheni.

Tugarinova, V N; Zolotnitskaia, R P; Lavrova, L A; Milovanova, Z P; Shmul'ian, T R.

Patol Fiziol Eksp Ter ; (6): 37-41, 1979.

Article in Russian | MEDLINE | ID: mdl-542331

Subject(s)

Liver Cirrhosis, Experimental/drug therapy , Penicillamine/therapeutic use , Animals , Antigens/administration & dosage , Autoimmune Diseases/complications , Carbon Tetrachloride Poisoning/complications , Drug Evaluation, Preclinical , Liver/immunology , Liver/pathology , Liver Cirrhosis, Experimental/etiology , Liver Cirrhosis, Experimental/pathology , Male , Rabbits , Time Factors

[Change in the content of cytochromes in the mitochondrial respiratory chain of rabbit liver in the state of precirrhosis]. / Izmenenie soderzhaniia tsitokhromov dykhatel'noi tsepi mitokhondrii pecheni krolikov v sostoianii pretsirroza

Kotova, E N; Tugarinova, V N.

Patol Fiziol Eksp Ter ; (2): 25-8, 1975.

Article in Russian | MEDLINE | ID: mdl-1187205

Subject(s)

Cytochromes/metabolism , Liver Cirrhosis/metabolism , Mitochondria, Liver/metabolism , Oxygen Consumption , Animals , Energy Metabolism , Liver Cirrhosis/pathology , Rabbits

[Modeling of chronic hepatitis through the action of homologous hepatogenic antigens]. / Modelirovanie khronicheskogo gepatita vozdeistviem gomologichnykh gepatogennykh antigenov.

Tugarinova, V N; Zolotarevskii, V B; Miklashevskii, V E.

Patol Fiziol Eksp Ter ; 16(5): 28-33, 1972.

Article in Russian | MEDLINE | ID: mdl-4670451

Subject(s)

Antigens/administration & dosage , Disease Models, Animal , Hepatitis B/immunology , Liver/immunology , Animals , Autoimmune Diseases/immunology , Complement Fixation Tests , Hypersensitivity, Delayed , Immunization , Male , Rabbits

[Radiosensitizing effect of sodium persulfate]. / Radiosensibiliziruiushchee deistvie persul'fata natriia.

Lokshina, A M; Tugarinova, V N.

Med Radiol (Mosk) ; 12(2): 81-4, 1967 Feb.

Article in Russian | MEDLINE | ID: mdl-5616165

Subject(s)

Radiation-Sensitizing Agents/therapeutic use , Sarcoma 180/radiotherapy , Sulfates/therapeutic use , Animals , Male , Mice , Sodium

[A modification of the micromethod of the excretory function of the liver]. / Modifikatsiia mikrometoda bromsul'faleinovoi proby na ékskretornuiu funktsiiu pecheni.

Tugarinova, V N; Miklashevskii, V E; Skobtsova, G G.

Lab Delo ; 4: 218-20, 1967.

Article in Russian | MEDLINE | ID: mdl-4180752

Subject(s)

Liver Diseases/physiopathology , Liver/physiopathology , Sulfobromophthalein , Child , Humans , Methods

[Assessment of the functional status of the liver with the use of bromsulfalein loading in a sanitation-toxicological experiment]. / Otsenka funktsional'nogo sostoianiia pecheni s pomoshch'iu nagruzki bromsul'faleinom v sanitarno-toksiklogicheskom éksperimente.

Tugarinova, V N; Miklashevskii, V E.

Gig Sanit ; 31(11): 55-9, 1966 Nov.

Article in Russian | MEDLINE | ID: mdl-6002217

Subject(s)

Carbon Tetrachloride Poisoning/physiopathology , Chemical and Drug Induced Liver Injury/physiopathology , Liver Function Tests , Liver/physiopathology , Sulfobromophthalein , Animals , Colorimetry , Rabbits , Rats

[On the problem of the toxicity of trichloromethane (chloroform) in its peroral entry into the organism]. / K voprosu o toksichnosti trikhlormetana (khloroforma) pri peroral'nom postuplenii v organizm.

Miklashevskii, V E; Tugarinova, V N; Rakhmanina, N L; Iakovleva, G P.

Gig Sanit ; 31(8): 107-8, 1966 Aug.

Article in Russian | MEDLINE | ID: mdl-5993800

Subject(s)

Chloroform/toxicity , Water Pollution , Animals , Industrial Waste , Mice

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