1.
Vopr Med Khim
; 31(2): 87-90, 1985.
Article
in Russian
| MEDLINE
| ID: mdl-3923716
ABSTRACT
Content of cytochromes P-450 was lower in liver tissue of NZB mice strain as compared with the NZW strain. Lipid peroxidation in microsomal fraction was higher in females as compared with males (P less than 0.05); it was also higher in females of the NZB mice strain than in the NZW strain (P less than 0.05).
Subject(s)
Mice, Inbred NZB/metabolism , Microsomes, Liver/enzymology , Animals , Cytochrome P-450 Enzyme System/metabolism , Cytochrome b Group/metabolism , Cytochromes b5 , Edetic Acid/pharmacology , Electron Transport/drug effects , Enzyme Induction/drug effects , Female , Lipid Peroxides/metabolism , Lupus Erythematosus, Systemic/etiology , Male , Mice , Microsomes, Liver/drug effects , Oxidation-Reduction/drug effects , Phenobarbital/pharmacology , Sex Characteristics
2.
Tsitol Genet
; 18(6): 458-9, 1984.
Article
in Russian
| MEDLINE
| ID: mdl-6441320
ABSTRACT
Spontaneous and mitomycin-C-induced chromosomal aberration level was studied in bone marrow cells of mice F1 (NZBXNZW), an experimental model of systemic lupus erythematosus and in C57BL/6J mice. The chromosome instability level is found to correspond to the degree of the autoimmune process: F1 (NZBXNZW) mice with the highest titer of autoantibodies to DNA has higher chromosomal mutability.
