Subject(s)
Niacinamide/pharmacology , Niacinamide/therapeutic use , Animals , Cardiomyopathies/drug therapy , Diabetes Mellitus/drug therapy , Diabetes Mellitus, Experimental/drug therapy , Humans , Nervous System/drug effects , Nervous System/metabolism , Niacinamide/metabolism , Receptors, Nicotinic/metabolismABSTRACT
Experiments on adult rabbits with experimental atherosclerosis induced by cholesterol (0.25 g/kg for 90 days) showed that chronic administration of trimethylglycine (1.5 g/kg for 30 days) prevented a decrease of the liver and myocardium content of nicotinamide coenzymes and adenine nucleotides.
Subject(s)
Adenine Nucleotides/metabolism , Arteriosclerosis/drug therapy , Betaine/therapeutic use , NADP/metabolism , NAD/metabolism , Animals , Arteriosclerosis/metabolism , Drug Evaluation, Preclinical , Energy Metabolism/drug effects , Heart/drug effects , Liver/drug effects , Liver/metabolism , Myocardium/metabolism , Oxidation-Reduction/drug effects , RabbitsSubject(s)
Adenosine Monophosphate/therapeutic use , Adenosine Triphosphate/therapeutic use , Cardiovascular Diseases/drug therapy , Humans , Liver Diseases/drug therapy , Mental Disorders/drug therapy , Nervous System Diseases/drug therapy , Neurotransmitter Agents/therapeutic use , Receptors, Neurotransmitter/drug effectsSubject(s)
NADP/metabolism , NAD/metabolism , Animals , Anticoagulants/pharmacology , Cardiovascular Diseases/metabolism , Chlorpromazine/pharmacology , Ethylene Dichlorides/metabolism , Female , Humans , Immunosuppressive Agents/pharmacology , Myocardial Infarction/metabolism , Neoplasms, Experimental/metabolism , Nikethamide/pharmacology , Nitroglycerin/pharmacology , Papaverine/pharmacology , Poisons/pharmacology , Radiation Injuries, Experimental/metabolism , Rats , Reserpine/pharmacology , Rheumatic Diseases/metabolism , Strophanthins/pharmacology , Theophylline/pharmacologySubject(s)
Blood Vessels/metabolism , Hypertension, Renal/metabolism , Myocardium/metabolism , Sympatholytics/therapeutic use , Animals , Chlorine/metabolism , Electrolytes/metabolism , Guanethidine/therapeutic use , Hypertension, Renal/drug therapy , Male , Muscle, Smooth/metabolism , Potassium/metabolism , Rats , Reserpine/therapeutic use , Sodium/metabolism , Water-Electrolyte BalanceABSTRACT
It was shown in experiments on rabbits that administration of octadine (10 mg/kg) and of ornid (10 mg/kg) and 1 hour (respectively) before the assessment failed to cause and changes in the adenylic nucleotides and inorganic phosphorus content in the aortic wall. Octadine administration led to reduction of the catecholamine level, but ornid, administered once or repeatedly, failed to cause any changes in the tissue catecholamine content. Repeated administration of these drugs in the same doses for 10 days caused an increase in the adenosinmonophosphoric acid content alone, without any essential changes in the other adenylic nucleotides and inorganic phosphorus content. An increase in the adenosinmonophosphoric acid content can be regarded as one of the mechanisms of pharmaco-mechanical relaxation of the smooth muscles in the vascular wall.