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J Chromatogr B Biomed Sci Appl ; 689(1): 117-22, 1997 Feb 07.
Article in English | MEDLINE | ID: mdl-9061487

ABSTRACT

The replacement of conventional hemodialysis treatment for a patient with malfunctioning kidneys by providing him/her with a portable and disposable "artificial kidney" which is connected to implanted artery and veneous cannulas on a patient's wrist is discussed. During a continuous flow of blood, plasma diffuses through a plasmapheretic membrane, passes through a bed of plasmacompatible sorbent Styrosorb, and arrives at an ultrafiltration membrane. Vacuum-operated ultrafiltration removes excess water together with dissolved urea and other small molecules, and Stryosorb removes medium-sized toxic substances. The hemocompatibility of the sorbent is improved by chemical modification of the surface.


Subject(s)
Biocompatible Materials , Hemofiltration/methods , Kidneys, Artificial , Polystyrenes/therapeutic use , Humans , Renal Dialysis , Ultrafiltration
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