ABSTRACT
A series of 22 men underwent a 30 minute carbon dioxide bath and was simultaneously administered Hydrochlorothiazide SPOFA. Their renal response was studied, and that both separately to the bath or the diuretic and to their combination. Diuresis was increased by 200 l x 10(-3) after the carbon dioxide bath and by 500 l x 10(-3) after hydrochlorothiazide. This increase was even further enhanced after the combination of the two treatments. Sodium excretion showed a similar increase, whereas kaliuresis did not exhibit such a marked rise and the differences between the response to the bath and to the diuretic were small. Repeated combination of the carbon dioxide bath and the diuretic resulted in a slightly increasing diuresis over the days studied. The authors emphasize the necessity to understand the bath--drug interactions particularly in balneological practice and substantiate the advantage and usefulness of the combination studied in indicated cases.
Subject(s)
Balneology , Carbon Dioxide/administration & dosage , Hydrochlorothiazide/administration & dosage , Kidney/metabolism , Adult , Combined Modality Therapy , Diuresis/drug effects , Humans , Male , Middle Aged , Natriuresis/drug effects , Potassium/urineABSTRACT
Sympathoadrenal activity was evaluated in 6 healthy subjects by excretory rate of adrenaline and noradrenaline in 6 hour samples of urine throughout three consecutive days. Subjects were exposed to natural sunlight for 4 hours on the second day of experiment, the first and third days served for control measurements. Sunbath caused erythema in all subjects and it had no impact adrenaline on excretion. However, significantly higher no radrenalineexcretion was present during 6 hours after exposition to sunshine when compared to control days.
