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Early, Real-Time Medical Diagnosis of Botulism by Endopeptidase-Mass Spectrometry.

Rosen, Osnat; Feldberg, Liron; Gura, Sigalit; Brosh-Nissimov, Tal; Guri, Alex; Zimhony, Oren; Shapiro, Eli; Beth-Din, Adi; Stein, Dana; Ozeri, Eyal; Barnea, Ada; Turgeman, Amram; Ben David, Alon; Schwartz, Arieh; Elhanany, Eytan; Diamant, Eran; Yitzhaki, Shmuel; Zichel, Ran.

Clin Infect Dis ; 61(12): e58-61, 2015 Dec 15.

Article in English | MEDLINE | ID: mdl-26420800

ABSTRACT

Botulinum toxin was detected in patient serum using Endopeptidase-mass-spectrometry assay, although all conventional tests provided negative results. Antitoxin was administered, resulting in patient improvement. Implementing this highly sensitive and rapid assay will improve preparedness for foodborne botulism and deliberate exposure.

Subject(s)

Botulism/diagnosis , Endopeptidases/blood , Mass Spectrometry/methods , Antitoxins/administration & dosage , Botulism/therapy , Early Diagnosis , Humans , Infant , Male , Serum/chemistry , Time Factors , Treatment Outcome

ABSTRACT

Subject(s)

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