[Combined endolymphatic therapy in patients with diffuse peritonitis]. / Kombinirovannaia éndolimfaticheskaia terapiia u bol'nykh s razlitym peritonitom.

The results of treatment of 25 patients with diffuse peritonitis whom the combined endolymphatic therapy was conducted in postoperative period, including the lymph irradiation with helium-neon laser and direct endolymphatic antibacterial therapy, are presented. Catheter was used introduced in peripheral lymph vessel on the dorsal surface of foot. The decrease of organism intoxication, more rapid than in control, was noted.

[Middle molecular weight peptides from rat blood serum during acute liver injury and administration of iodinated oil]. / Srednemolekuliarnye peptidy syvorotki krovi krys pri ostrom povrezhdenii pecheni i vvedenii iodirovannogo masla.

A spectrum of mean-molecular blood serum peptides in rats with experimental toxic hepatitis and parenteral injection of iodinated oil has been studied using the method of gel-filtration on a sephadex G-25. It is established that the toxic hepatitis is characterized by the expressed rearrangement of the stock of mean-molecular peptides with a preferential growth in the blood serum and normalization of their concentrations 24h after the injection of iodinated oil accompanied by attenuation of the organism intoxication phenomena. An increase in the content of mean-molecular peptides was registered 48 hours after the iodinated oil injection.

[Status of the thyroid gland in patients with schizophrenia]. / Tireoidnyi status bol'nykh shizofreniei.

A study was made of pituitary-thyroid function in patients with different forms of schizophrenia. Radioimmunoassay was used. All the patients with schizophrenia showed impairment of interrelations within the pituitary-thyroid system, which manifested by accumulation in the peripheral blood of metabolically active T3 due to enhanced degradation of T4 in the peripheral tissues. The rise of TTH concentration represents one of the mechanisms of correction, aimed at the attainment of the physiological content of T4 at the expense of its additional output for its level in the blood serum is appreciably reduced.

[Amino acid reserves of the blood in patients with schizophrenia and their correction in insulin coma]. / Aminokislotnye rezervy syvorotki krovi u bol'nykh shizofreniei i ikh korrektsiia pri insulinovoi kome.

Free amino acid content was measured in the blood serum in patients with permanently progressive paranoid schizophrenia under conventional insulin shock therapy. The influence of several amino acids (methionine, glutamic acid) preinjection on their base levels was also assessed. Metabolic response to the insulin coma was different in preinjected vs. control groups. Glutamine acid-preinjected patients displayed less pronounced shifts in amino acid reserves in the blood serum that smoothed the shock-related metabolic stress in these patients as related to conventional shock.

[Free amino acids and the total middle molecule fraction of the blood serum in patients with continuously progressive paranoid schizophrenia undergoing treatment]. / Svobodnye aminokisloty i obshchaia fraktsiia srednikh molekul syvorotki krovi bol'nykh nepreryvno protekaiushchei paranoidnoi shizofreniei, nakhodiashchikhsia na lechenii.

The authors have investigated the levels of free amino acids and of the total fraction of medium molecules in the blood serum of patients with the paranoid form of continuously progressive schizophrenia. It has been demonstrated that these parameters are different in clinically normal individuals versus schizophrenics. The concentrations of free amino acids were the highest in people aged 40 to 50 years (Cys, Ala, Lys, Asp, Thr, Tyr, Try, Val, Leu, Ile) being considerably lower in individuals aged 50 to 60 years (Cys, Ala, Tyr) and over 60 years (Lys, His, Asp, Tyr, Try) which corresponds to the highest activity of the process in patients aged 40 to 50 years and its stabilization in older age.

[Middle-molecule spectrum of the blood serum in patients with a continuously progressive paranoid form of schizophrenia undergoing treatment]. / Srednemolekuliarnyi spektr syvorotki krovi bol'nykh nepreryvno progredientnoi paranoidnoi formoi shizofreniei, nakhodiashchikhsia na lechenii.

Screening and gel filtration on Sephadex G-15 (Pharmacia, Sweden) were used to study mean molecular (MM) components (the level of total fraction and spectrum) in the serum of patients suffering from continuously progressing paranoid schizophrenia. The findings evidenced elevated level of the fraction and rearranged spectrum of the components. MM components 5 significant increase and peaks I decrease registered in the study may play a role in pathogenesis of the disease and underlie the development of its productive symptoms.

[Middle molecule fraction in the serum of rats with toxic hepatitis]. / Fraktsii srednikh molekul syvorotki krovi u krys pri toksicheskom gepatite.

An increase in the amount of the middle molecular peptide (MM) fraction in the blood serum of rats with experimental toxic hepatitis and normalization of the MM pool after the administration of the amino acid mixture Alvesin "Novy" are shown. The chromatographic spectra of the MM fraction in normal and experimental animals are compared.

[Free amino acids in brain tissue and its subcellular structures in hyperthermia in rats]. / Svobodnye aminokisloty v tkani mozga i ego subkletochnykh strukturakh pri gipertermii u krys.

Free amino acids reserves in the brain tissue, nuclei and mitochondria were investigated in mongrel albino rats under conditions of hyperthermia (45 degrees C) of different duration--7,20 and 60 min. It was found that reserves of most free amino acids in the albino rat brain decreased under a short-term (7 min) hyperthermia and accumulated under more prolonged (20-60 min) one. The amount of amino acids in the brain mitochondria increased 7 min after the experiment start and decreased 20 min later, then (60 min later) the amount of most amino acids increased considerably. Opposite shifts were detected in the content of most amino acids in nuclei.

[Free amino acids in the brain of vertebrates]. / Svobodnye aminokisloty v golovnom mozge nekotorykh pozvonochnykh.

Studies have been made on the content of free amino acids in the brain of the pike Esox lucius, frog Rana ridibunda, pheasant Phasinus colhidus, hare Lepus europaeus, as well as their distribution in the white and grey matter of healthy human subjects. Differences in the distribution of free amino acid pool were found between man and animals. In the grey matter of human brain, large quantities of free ornithine, phenylalanine, lysine, serine, glycine, alanine, tyrosine, tryptophan, methionine, leucine and isoleucine, as well as lower level of aspartic acid, glutamic acid and threonine were found as compared to the white matter. The content of ornithine, serine and threonine increases in the row birds greater than fishes greater than man greater than mammals greater than amphibians; histidine and arginine pool increases in the following sequence: birds greater than fishes greater than mammals greater than amphibians greater than man.

[Distribution of free amino acids in the rat brain during ontogenesis]. / Raspredelenie svobodnykh aminokislot v mozgu krys v ontogeneze.

Distribution of free amino acids reserves in the brain tissues, nuclei and mitochondria of rats is studied in ontogenesis dynamics. It is established that the content of most amino acids in tissues and mitochondria increases by the 6-month age, lowers in the brain tissues and subcellular structures by the 12-month age, decreases in the tissues and nuclei and grows in mitochondria of old animals. The reasons of disbalance in distribution of the reserves of free amino acids are under discussion.

[Dynamics of free amino acids in rat brain tissue during hypothermia]. / Dinamika svobodnykh aminokislot v tkaniakh mozga krys pri gipotermii.

A comparative study is conducted for the effect of one-, three- and six-hour artificial deep (20-19 degrees C) hypothermia on the content of free amino acids in the blood serum, tissue, nuclei and mitochondria of the rat brain. It is found out that the content is the highest in the blood serum after a three-hour cooling. In the brain tissue the amount of amino acids lowers, especially under conditions of a six-hour hypothermia. In nuclei a three-hour effect of hypothermia decreases sharply the content of free amino acids and the six-hour one increases the amount of most of them. Under hypothermia the content of nearly all amino acids in the brain mitochondria is higher than in the intact animals.

[Dynamics of the content of free amino acids in the liver and serum of rats during ontogenesis]. / Dinamika soderzhaniia svobodnykh aminokislot v pecheni i syvorotke drovi krys v ontogeneze.

Dynamics of free amino acid reserves in newborn 3, 6, 12 and 24-month rats was studied in ontogenesis. At all stages of postnatal life they get distributed differently in the liver and blood serum. Both individual and common peculiarities of amino acidic reserve distribution are marked.