1.
Org Lett
; 4(18): 3111-4, 2002 Sep 05.
Article
in English
| MEDLINE
| ID: mdl-12201729
ABSTRACT
[reaction: see text] Treatment of formyl alpha,beta-enones with a TiCl(4)-R(4)NX combination induces an intramolecular aldol cyclization to furnish 2-acyl-3-halocyclohexanol with three controlled consecutive stereogenic centers. The reaction of bis-alpha,beta-enones with the combination provides cyclic diketones with high stereoselectivity via an intramolecular Michael addition reaction.