Sex-based differences in expectations for social communication after TBI.

Sex-based differences have been reported in several TBI outcome studies, including studies of social functioning. In some studies, social outcomes have been evaluated via perceptual judgments on questionnaires, which may be influenced by stereotypes about acceptable behaviour for men and women. To explore potential sex-based rater bias in social judgments, we asked 68 typical undergraduates (34 women) to identify problematic behaviour for men vs. women on a widely used questionnaire for TBI social outcome, the LaTrobe Communication Questionnaire. Results revealed more consensus among raters of both sexes about acceptable behaviours for men than behaviours for women, and women were more critical than men when judging persons of either sex. These findings support the importance of considering sex in TBI social outcome research, past and future, not only sex of the participant but also sex of the person judging social outcome. Sex-based differences here also have implications for social evaluations in clinic, where female clinicians are often judging male patients. Future research should consider gender (the social construct), as well as sex (the biological construct), as both may contribute to perceived social outcome after TBI.

Impaired theory of mind in adults with traumatic brain injury: A replication and extension of findings.

OBJECTIVE: To replicate a previous study of Theory of Mind (ToM) task performance in adults with traumatic brain injury (TBI) under different working memory (WM) demands, and determine if there are sex-based differences in effects of WM load on ToM task performance. METHOD: 58 adults with moderate-severe TBI (24 females) and 66 uninjured adults (34 females) matched group-wise for age, sex, and education viewed a series of video vignettes from the Video Social Inference Task (VSIT) (Turkstra, 2008) and answered ToM questions. Vignette presentation format required updating and maintenance of information, and WM load was manipulated by varying presence of distracters. RESULTS: There were main effects of group and WM load, no significant effect of sex, and a marginal interaction of group by WM load, with larger between-group differences in conditions with higher WM load. VSIT scores for the condition with the highest WM load were significantly correlated with scores on the first trial of the California Verbal Learning Test. CONCLUSIONS: We replicated findings of lower scores in adults with TBI on a video-based ToM task, and provided additional evidence of the effect of WM load on social cognition task performance. There were no significant accuracy differences between men and women, inconsistent with prior evidence - including our own data using the same test. There is strong evidence of a female advantage on other social cognition tasks, and the parameters of this advantage remain to be discovered.

Relationship between individual differences in functional connectivity and facial-emotion recognition abilities in adults with traumatic brain injury.

Although several studies have demonstrated that facial-affect recognition impairment is common following moderate-severe traumatic brain injury (TBI), and that there are diffuse alterations in large-scale functional brain networks in TBI populations, little is known about the relationship between the two. Here, in a sample of 26 participants with TBI and 20 healthy comparison participants (HC) we measured facial-affect recognition abilities and resting-state functional connectivity (rs-FC) using fMRI. We then used network-based statistics to examine (A) the presence of rs-FC differences between individuals with TBI and HC within the facial-affect processing network, and (B) the association between inter-individual differences in emotion recognition skills and rs-FC within the facial-affect processing network. We found that participants with TBI showed significantly lower rs-FC in a component comprising homotopic and within-hemisphere, anterior-posterior connections within the facial-affect processing network. In addition, within the TBI group, participants with higher emotion-labeling skills showed stronger rs-FC within a network comprised of intra- and inter-hemispheric bilateral connections. Findings indicate that the ability to successfully recognize facial-affect after TBI is related to rs-FC within components of facial-affective networks, and provide new evidence that further our understanding of the mechanisms underlying emotion recognition impairment in TBI.

Social information processing in adolescents: data from normally developing adolescents and preliminary data from their peers with traumatic brain injury.

OBJECTIVE: To assess aspects of social information processing in naturalistic conversations, using online videotape tasks. DESIGN AND PARTICIPANTS: The tasks were administered to 60 normally developing (ND) subjects ages 13 to 21, and 10 adolescents with traumatic brain injury (TBI). SETTING: University. MAIN OUTCOME MEASURE: Task accuracy scores and measures of reliability and validity. RESULTS AND CONCLUSIONS: ND group scores were generally high, without significant differences by race, sex or age. TBI group scores were significantly lower than ND group scores for both emotion recognition and detection of conversation skills. The results are discussed in light of the evaluation of pragmatic competence in adolescents with TBI.

Treating memory problems in adults with neurogenic communication disorders.

Historical approaches to memory therapy have focused on rehearsal or "relearning" of memory skills and on compensation for impairments. Whereas the use of rehearsal-based approaches has received little empirical support, the use of external compensatory devices has proved helpful to patients with a variety of neurogenic communication disorders. More recent approaches have capitalized on advances in cognitive psychology, permitting the identification of strengths and weaknesses in specific memory functions, and increasing our understanding of the role of response errors in the therapy process. These advances, together with applied behavioral analysis, allow therapy to be tailored to the cognitive profile of an individual patient, and help explain the successes and failures of earlier techniques. In this article, both historical and current approaches are discussed, and memory therapy guidelines are suggested.

Partner effects in adolescent conversations.

UNLABELLED: Twenty-four adolescents participated in social conversations with a same-sex peer, an opposite-sex peer, or a speech-language pathologist (SLP) or graduate student. The conversations were compared in regard to specific verbal and nonverbal behaviors, with the goal of identifying conversational behaviors that may be assessed with validity in a clinical setting. Significant differences were found in speaker and listener linguistic behaviors between conversations with peers and those with clinicians. A trend towards the increase in speaker nonverbal behaviors was also noted with clinician partners. Conversations with opposite-sex peers tended to be characterized by fewer direct questions, reduced listener eye contact, and increased listener nonverbal behaviors than those with same-sex peers. Several behaviors occurred rarely in any group, including physical contact between partners and requests for clarification; others occurred with high frequency in all groups, including eye contact and emotional expression. The implications of these patterns for persons with communication disorders are considered. EDUCATIONAL OBJECTIVES: (1) To describe communication behaviors that may be measured in adolescent conversations. (2) To identify those communication behaviors that may be influenced by factors related to the conversation partner.

Use of elaborative encoding to facilitate verbal learning after adolescent traumatic brain injury.

OBJECTIVE: To investigate the effectiveness of elaborative encoding in learning and remembering word definitions after traumatic brain injury (TBI). DESIGN: Two case studies. SETTING: University outpatient clinic. PARTICIPANTS: Two adolescents with severe memory impairments after TBI who needed specific vocabulary for school. INTERVENTIONS: A series of individual speech-language therapy sessions incorporating clinician- and subject-generated strategies to facilitate elaborative encoding. Target words were based on school requirements and pretreatment test results and were assigned randomly to treatment or control groups. MAIN OUTCOME MEASURE: Accuracy of free-recalled definitions at the conclusion of therapy and after 1 month with no therapy. RESULTS: Significant improvement in expressed word knowledge at the conclusion of therapy, with improvement on treated words maintained at 1 month for both subjects. CONCLUSIONS: Elaborative encoding was an effective tool for teaching specific information required for school. Patterns of response differed substantially from those of normally developing children. Generalization to classroom use was planned for and should be measured in future research.

Assessment of syntax after adolescent brain injury: effects of memory on test performance.

In this study, we investigated the influence of working memory load on performance of a task designed to measure receptive syntax ability. Subjects were 6 brain-injured adolescents and 6 hospitalized control subjects matched for age, sex, and general ability. Each subject was administered the Listening/Grammar subtest of the Test of Adolescent Language (TOAL-3) and a modified version of this subtest with identical syntax and fewer response choices (i.e., a reduced working memory processing and storage load). The syntactic structures tested on these tasks also were measured in spontaneous narratives. The brain-injured subjects' performance was significantly worse than that of controls on both versions of the syntax comprehension subtest. There was a significant group-by-task interaction, as brain-injured subjects' performance was significantly worse on the Listening/Grammar subtest than the modified subtest, whereas Control subjects'performance did not differ across the two tasks. In their spontaneous narratives, subjects in both groups produced the syntactic structures tested on the receptive syntax tasks, with no between-groups difference in syntax production. The results are discussed in terms of test validity and the impact of measurement methods on test performance in disordered groups.

Assessment of pragmatic communication skills in adolescents after traumatic brain injury.

Deficits in pragmatic communication ability have a significant impact on functional outcome from traumatic brain injury (TBI), particularly during adolescence, when sophisticated social communication skills are developing. There are few published tests designed to assess pragmatic skills in this age group. In the present study, four tasks designed to tap various aspects of pragmatic communication ability were administered to three brain-injured adolescents and 36 of their uninjured peers aged 15-18 years. The tasks evaluated the ability to negotiate, hint, describe a simple procedure, and understand sarcasm. The four tasks were found to tap distinct aspects of pragmatic ability in control subjects. Further, within the control group, task performance was related more to non-verbal reasoning ability than vocabulary skills. Scores for two of the three TBI subjects were poorer than those of their peers, while a third mildly injured subject performed within normal limits. Pragmatic task scores were consistent with the results of neuropsychological testing in the three TBI subjects. Implications for clinical management and recommendations for future research are discussed.

Electrodermal response and outcome from severe brain injury.

The relation of electrodermal response measures to outcome from early post-traumatic vegetative state (VS) was investigated in 15 brain-injured and five control subjects. Brain-injured subjects were in acute VS or persistent VS (PVS), or had recovered from acute VS (RVS). Significant group differences were found on all electrodermal response measures, primarily due to the greater amplitude, number and consistency of responses in control subjects. Group differences in electrodermal habituation and orientation to auditory tones reflected the absence of orientation in most RVS subjects and the absence of both habituation and orientation PVS subjects. The groups differed in their response to matching faces and names. All of the control subjects, two of five RVS subjects and none of five acute subjects produced significant responses. Surprisingly, two PVS subjects also produced significant responses. For acute subjects a positive outcome at 6 months post-trauma was associated with early electrodermal startle amplitude and baseline lability. These results indicate that electrodermal responsiveness is generally reduced following acute VS, even in subjects with a relatively good recovery. Greater electrodermal activity in early VS may be associated with better potential for recovery.

Acquired mutism: physiopathy and assessment.

The speechless patient presents a unique challenge to the clinician working with neurologically impaired adults. Acquired speechlessness, or mutism, has been associated with a variety of clinical states and syndromes after damage to central and peripheral nervous system structures. The intent of this paper is to summarize the reported states and syndromes associated with acquired mutism (eg, persistent vegetative state, akinesia), and to organize this information in a framework for clinical assessment of the speechless patient. For the purpose of discussion, speech production is divided into five interrelated processes: arousal; cognitive processing; affect and drive; motor initiation, planning, programming, and coordination; and execution of movement. Disorders characterized by mutism are classified according to the process or processes of speech production that primarily are affected. Each subtype of acquired mutism is characterized by a cluster of neurologic signs, which has been incorporated into a decision-making framework for use in a clinical setting.