Binaphthol-catalyzed asymmetric conjugate arylboration of enones.

Conjugate addition of arylboronates to α,ß-unsaturated ketones may be catalyzed by chiral binaphthols with enantioselectivities of up to 99:1. Best results were observed with 3,3'-dichloro-BINOL. This chemistry was applied to syntheses of intermediates for syntheses of (+)-indatraline and (+)-tolterodine.