1.
Chemistry
; 26(14): 3026-3029, 2020 Mar 09.
Article
in English
| MEDLINE
| ID: mdl-31922300
ABSTRACT
A radical domino cyclisation reaction of N-cyanamide alkenes, mediated by hydrogen atom transfer (HAT) has been developed. This method, using PhSiH3 and catalytic Fe(acac)3 , allows for the synthesis of challenging (spiro)quinazolinone scaffolds from simple, tractable (hetero)aryl carboxylic acid and cyanamide building blocks.
2.
Chemistry
; 24(70): 18658-18662, 2018 Dec 12.
Article
in English
| MEDLINE
| ID: mdl-30341926
ABSTRACT
Hydrogen atom transfer-mediated intramolecular C-C coupling reactions between alkenes and nitriles, using PhSiH3 and catalytic Fe(acac)3 , are described. This introduces a new strategic bond disconnection for ring-closing reactions, forming ketones via imine intermediates. Of note is the scope of the reaction, including formation of sterically hindered ketones, spirocycles and fused cyclic systems.