ABSTRACT
OBJECTIVE: We report our experience during the past 10 years in the management of accidental punctures. PATIENTS AND METHODS: A study was made of all hypodermic needle punctures recorded in children aged 0-14 years in our center since 1987. A clinical protocol consisting of 5 visits and duration of 6-7 months was used in all cases. RESULTS: A total of 150 punctures were recorded during the study period with a decrease in prevalence over time. All cases the clinical protocol was accepted and correct follow-up procedures were performed. In no case was post-puncture sero-conversion detected for HCV, HBV, or HIV among correctly immunized children. CONCLUSIONS: The protocol employed is useful and well accepted with the risk of infection caused by accidental puncture being remote provided initial patient care was adequate.
Subject(s)
Accidents , Needles , Wounds, Penetrating/prevention & control , Child , Clinical Protocols , Female , Humans , Infant , Infant, Newborn , Male , Retrospective StudiesABSTRACT
After programme a inquiry-type this carry out itself amongst the families that adopted children with antibodies from the human immunodeficiency virus (AcVIH) in, they communicate the facts collected about the problematic that raise their adoption. They provide some conclusions.
Subject(s)
Acquired Immunodeficiency Syndrome , Adoption , HIV Seropositivity , Child , Humans , SpainABSTRACT
BACKGROUND: A clinical, histologic, immunohistochemical, serological and evolutive review was carried out in 12 cases of Kaposi's sarcoma, representing 5.5% (12/217) of the HIV positive patients consecutively seen during an 18 month period. METHODS: The patients were clinically examined and staging was assessed. Skin biopsy was performed in all cases, and of healthy perilesional skin in eight, with HE and Perls stains. Immunohistochemical study of the skin lesions was carried out with monoclonal anti-collagen, anti-laminin, anti-HLA-DR, OKM5 and UEA-I antibodies. Statistical analysis was carried out with chi-square and Student's tests. RESULTS: There were 11 homosexual males and a prostitute parenteral drugs addicted female. The clinical presentation spectrum ranged from a single longitudinal lesion to multiple disseminated lesions in the whole skin and mucosae. Visceral or lymph node involvement was shown in three cases. Histological study also showed a spectrum of lesions from initial endothelial proliferation in perilesional healthy skin areas to mixed fusocellular and endothelial proliferation in nodular lesions. The immunohistochemical study with the appropriate monoclonal antibodies demonstrated the endothelial origin of cellular components. Some laboratory parameters (beta-2-microglobulin, total lymphocytes/mm3, total CD4 cells/mm3) were useful for prognostic evaluation at the time of diagnosis. CONCLUSIONS: KS associated with HIV infection is a vascular hyperplasia of endothelial origin virtually exclusive of homosexual males. Although the diagnose of KS does not determine by itself the vital prognosis of these patients, some laboratory parameters at the time of diagnosis are useful for the prognosis of HIV infection.
Subject(s)
HIV Infections/complications , Sarcoma, Kaposi/etiology , Skin Neoplasms/etiology , Acquired Immunodeficiency Syndrome/complications , Adult , Female , HIV Seropositivity/complications , Humans , Male , Middle Aged , Prognosis , Sarcoma, Kaposi/diagnosis , Sarcoma, Kaposi/pathology , Skin/pathology , Skin Neoplasms/diagnosis , Skin Neoplasms/pathologyABSTRACT
We study 37 children with mothers infected by human immunodeficiency virus type 1 (HIV-1) at birth and over the following three years. HIV-1 serology of these patients is reported, i.e., HIV-1 antigen p24 and antibodies using two commercially available enzymatic methods and Western blot. Throughout follow-up, IgG antibodies to HIV-1 showed a statistically significant tendency to decrease (p less than 0.001). After 12 months, 70% of the children lacked HIV-1 antibody banding by Western blot; this was taken to constitute a definitive criterion of lack of antibodies to HIV-1. Five children presented p24 antigenemia during the study, four persistently so. Of the patients over 18 months of age, 8 presented HIV-1 infection symptoms (30.7%), and three suffered AIDS (11.5%).
Subject(s)
Acquired Immunodeficiency Syndrome/transmission , HIV Seropositivity , HIV-1/immunology , Acquired Immunodeficiency Syndrome/immunology , Child, Preschool , Female , HIV Antibodies/immunology , Humans , Infant , Infant, Newborn , Male , Maternal-Fetal Exchange , PregnancyABSTRACT
A social study is made of 60 families with offspring presenting antibodies to HIV and monitored in our Service. Their data are compared with those obtained from an HIV antibody-negative control population randomly extracted from our Center.