ABSTRACT
Effect of trans-anetol (t-An) as nutritive addition to cytochrome P-450 containing system (MOS) of liver of rats was studied. It was shown, that t-An rendered inducing action to MOS, which depended on degree of action. It was established that simultaneous effect of t-An and mixture of polychlorinated diphenyles (sovol) modified inducing action of sovol to cytochrome P-450 system, Simultaneous effect of t-An and mixture of polychlorinated diphenyles increased hepatotoxic action of these xenobiotics.
Subject(s)
Anisoles/toxicity , Cytochrome P-450 Enzyme System/drug effects , Flavoring Agents/toxicity , Liver/drug effects , Polychlorinated Biphenyls/metabolism , Allylbenzene Derivatives , Animals , Anisoles/administration & dosage , Cytochrome P-450 Enzyme System/metabolism , Flavoring Agents/administration & dosage , Liver/metabolism , Male , Rats , Rats, WistarABSTRACT
The fusariotoxins' content in the in-plant air of the flour mill and its effect on the workers' health status were investigated.
Subject(s)
Air Pollutants, Occupational/analysis , Air Pollution, Indoor/analysis , Flour , Food-Processing Industry , Health Status , T-2 Toxin/analysis , HumansABSTRACT
The total and non-sedimentable activities of liver beta-galactosidase, beta-glucoronidase, beta-N-acetyl glucosaminidase, aryl sulfatases A and B were studied during antigenic stimulation of rats fed balanced and low-protein (5% of energy value) diets. Antigenic stimulation of rats fed a balanced diet was found to intensify the total activities of all lysosomal enzymes (up to 124-246% of control). Meanwhile protein deficiency did not cause any significant reduction in immune response and completely removed activation of lysosomal hydrolases.
