1.
J Clin Pharmacol
; 21(11): 615-9, 1981.
Article
in English
| MEDLINE
| ID: mdl-7338572
ABSTRACT
In 58 clinical studies, adverse reactions to bumetanide were evaluated in 493 patients and compared with those in 220 patients treated with furosemide. The comparison diuretics were administered to patients with edema secondary to congestive heart failure, and renal and hepatic disease. In addition to observation of clinical variables, laboratory tests were done to evaluate the effects of the diuretics on serum electrolyte levels. The results indicate that bumetanide, as furosemide, is an effective diuretic free of significant adverse effects when administered in doses within the recommended therapeutic dose range. Audiometric studies suggest that bumetanide is possibly safer than furosemide with regard to ototoxicity.
Subject(s)
Bumetanide/adverse effects , Diuretics/adverse effects , Furosemide/adverse effects , Breast/drug effects , Edema/drug therapy , Electrolytes/blood , Hearing/drug effects , Heart Failure/drug therapy , Humans , Kidney Diseases/drug therapy , Liver Diseases/drug therapy
2.
Curr Ther Res Clin Exp
; 17(1): 95-106, 1975 Jan.
Article
in English
| MEDLINE
| ID: mdl-806434
Subject(s)
Ferricyanides/therapeutic use , Hypertension/drug therapy , Nitroprusside/therapeutic use , Adolescent , Adult , Aged , Blood Pressure/drug effects , Emergencies , Female , History, 19th Century , Humans , Injections, Intravenous , Male , Middle Aged , Nitroprusside/administration & dosage , Nitroprusside/adverse effects , Posture , Time Factors
3.
J Clin Pharmacol
; 14(10): 494-503, 1974 Oct.
Article
in English
| MEDLINE
| ID: mdl-4610012
Subject(s)
Antihypertensive Agents/therapeutic use , Ferricyanides/therapeutic use , Hypertension/drug therapy , Administration, Oral , Adult , Aging , Anesthesia , Angiography , Antihypertensive Agents/administration & dosage , Antihypertensive Agents/adverse effects , Chemical Phenomena , Chemistry , Child , Ferricyanides/administration & dosage , Ferricyanides/adverse effects , Ferricyanides/toxicity , Heart Failure/drug therapy , Humans , Injections, Intravenous , Kidney Diseases/diagnosis , Myocardial Infarction/drug therapy , Nitric Oxide/administration & dosage , Nitric Oxide/adverse effects , Nitric Oxide/therapeutic use , Nitric Oxide/toxicity , Renin/metabolism , Tachyphylaxis/drug effects , Vascular Resistance/drug effects , Vasodilator Agents/pharmacology
4.
Psychosomatics
; 11(1): 50-4, 1970.
Article
in English
| MEDLINE
| ID: mdl-4908032