ABSTRACT
The effect of a single pre-operative oral dose of controlled release diclofenac sodium on post-operative pain after minor gynaecological surgery was investigated. Fifty-two women took part in a double-blind controlled study. Pain was assessed by visual analogue scale (VAS), a four-point verbal rating score, and the requirement for post-operative analgesia. Those patients who received diclofenac had significantly less post-operative pain than the placebo group up to 2 h after surgery.
Subject(s)
Analgesics, Non-Narcotic/therapeutic use , Diclofenac/therapeutic use , Genital Diseases, Female/surgery , Pain, Postoperative/prevention & control , Premedication , Analgesics, Non-Narcotic/administration & dosage , Anesthesia , Delayed-Action Preparations , Diclofenac/administration & dosage , Double-Blind Method , Female , Humans , Male , Pain MeasurementABSTRACT
During an attempt to measure renal function during operation in six patients undergoing major abdominal surgery involving intestinal resection and blood loss in excess of 300 ml, it became apparent that the conventional recommendation for i.v. crystalloid fluid of 5-10 ml kg-1 h-1 was not sufficient to maintain cardiovascular stability and urine output, but a volume of 15 ml kg-1 h-1, given to a subsequent six patients, was adequate. Administration of low sodium (glucose) solutions also produced biochemical abnormalities of a severity not documented previously. A survey of the published literature on volumes of crystalloid fluids used supports the contention that, during major surgery, crystalloid requirements may be of the order of 10-15 ml kg-1 h-1 rather than 5-10 ml kg-1 h-1.
Subject(s)
Abdomen/surgery , Fluid Therapy/methods , Plasma Substitutes/administration & dosage , Blood Pressure , Crystalloid Solutions , Glucose/administration & dosage , Humans , Infusions, Intravenous , Intraoperative Period , Isotonic Solutions , Random Allocation , Thymol/administration & dosage , Urination , Water-Electrolyte BalanceABSTRACT
The Trilite inhaler was developed for use in World War II. Its efficient performance is confirmed and a brief biography of its inventor is also given.
Subject(s)
Anesthesiology/history , Nebulizers and Vaporizers/history , History, 20th Century , Trichloroethylene , United KingdomABSTRACT
The hourly rectal temperature record of 15 patients who spent greater than or equal to 8 days in the ICU were analyzed for circadian rhythmicity. Using cosinor analysis, a statistically significant rhythm in a period of 24 h was present on 80% of the patient days studied. The position of the acrophase, or peak, of the rhythm varied markedly both between patients and within patients, with changes of several hours from day to day. There was a tendency for the amplitude of the rhythm to be greater when the patients were unconscious than when they were conscious and in those patients who died compared with those who survived.