Impact on prime animal beef merit from breeding solely for lighter dairy cows.

As the proportion of prime carcasses originating from dairy herds increases, the focus is shifting to the beef merit of the progeny from dairy herds. Several dairy cow total merit indexes include a negative weight on measures of cow size. However, there is a lack of knowledge on the impact of genetic selection, solely for lighter or smaller-sized dairy cows, on the beef performance of their progeny. Therefore, the objective of this study was to quantify the genetic correlations among cow size traits (i.e., cow body weight (BW), cow carcass weight (CW)), cow body condition score (BCS), cow carcass conformation (CC), and cow carcass fat cover (CF), as well as the correlations between these cow traits and a series of beef performance slaughter-related traits (i.e., CW, CC, CF, and age at slaughter (AS)) in their progeny. After data editing, there were 52,950 cow BW and BCS records, along with 57,509 cow carcass traits (i.e., CW, CC, and CF); carcass records from 346,350 prime animals along with AS records from 316,073 prime animals were also used. Heritability estimates ranged from moderate to high (0.18 to 0.62) for all cow and prime animal traits. The same carcass trait in cows and prime animals were strongly genetically correlated with each other (0.76 to 0.85), implying that they are influenced by very similar genomic variants. Selecting exclusively for cows with higher BCS (i.e., fatter) will, on average, produce more conformed prime animals carcasses, owing to a moderate genetic correlation (0.30) between both traits. Genetic correlations revealed that selecting exclusively for lighter BW or CW cows will, on average, result in lighter prime animal carcasses of poor CC, while also delaying slaughter age. Nonetheless, selective breeding through total merit indexes should be successful in breeding for smaller dairy cows, and desirable prime animal carcass traits concurrently, because of the non-unity genetic correlations between the cow and prime animal traits; this will help to achieve a more ethical, environmentally sustainable, and economically viable dairy-beef industry.

Differences in the choice of beef artificial insemination sires used by dairy producers versus beef producers.

The growing demand among dairy producers for suitable beef sires to mate to their females creates the possibility of separate breeding programs to generate beef sires for the dairy sector versus those for the beef sector. Informing such a decision is the extent of the genetic differences among beef sires used by dairy producers relative to those used by beef producers. The objective therefore of the present study was to use a large national database of artificial insemination (AI) records in dairy and beef cow herds to establish the difference in mean genetic merit of beef AI sires used by dairy producers versus those used by cow-calf beef producers. The traits explored were gestation length, calving difficulty, and perinatal mortality as well as the 3 carcass traits of carcass weight, conformation, and fat score. Carcass conformation and fat score are mechanically assessed on a scale of 1 (poor conformation and low fat cover) to 15 (excellent conformation and high fat cover). Sire genetic merit differences for feed intake and docility were also examined. Estimates of genetic merit for all 8 traits on individual AI sires available at the time of service were used. A total of 1,230,622 AI records comprised 909,719 services from dairy herds and 320,903 services from beef herds were used. Of the 1,802 beef AI sires represented in the entire dataset, over half were used by both dairy and beef herds representing ≥98% of the services in each production system. However, the usage rate of individual AI sires differed between dairy and beef herds with the Spearman rank correlation between the quantity of inseminations per sire in dairy and beef herds being just 0.38. This correlation means that beef AI sires used heavily in the beef herd were not always those heavily used in dairy herds. A clear difference in the mean genetic merit of beef AI sires selected by dairy producers relative to those selected by beef cow-calf producers was obvious with the extent of the difference being a function of whether the female served was a nulliparous heifer or a cow. Much of the differences in genetic merit of chosen beef AI sires between dairy and beef producers was actually attributable to differences in breed choice, albeit some within-breed selection was also evident. Irrespective, dairy producers, on average, chose shorter gestation length sires whose progeny were genetically less predisposed to require intervention during the birthing process; these sires had genetic merit estimates expected to result in lighter and less conformed progeny carcasses relative to the beef AI sires used by beef producers. Results point to large differences in genetic merit of the beef AI sires chosen by dairy versus beef producers, much of which actually reflected differences in breed choice among dairy and beef producers.

Mean breed performance of the progeny from beef-on-dairy matings.

Gains through breeding can be achieved through a combination of both between-breed and within-breed selection. Two suites of traits of particular interest to dairy producers when selecting beef bulls for mating to dairy females are calving-related attributes and the expected value of the subsequent calf, the latter usually being a function of expected carcass value. Estimated breed effects can be informative, particularly in the absence of across-breed genetic evaluations. The objective of the present study was to use a large national database of the progeny from beef-on-dairy matings to estimate the mean breed effects of the used beef sires. Calving performance (i.e., gestation length, calving difficulty score, and perinatal morality) as well as calf value were investigated; a series of slaughter-related traits (i.e., carcass metrics and age at slaughter) of the prime progeny were also investigated. Phenotypic data on up to 977,037 progeny for calving performance, 79,903 for calf price and 103,175 for carcass traits (including dairy × dairy progeny for comparative purposes) were used; sire breeds represented were Holstein-Friesian, Angus, Aubrac, Belgian Blue, Charolais, Hereford, Limousin, Salers, and Simmental. Large interbreed differences existed. The mean gestation length of male calves from beef sires varied from 282.3 d (Angus) to 287.4 d (Limousin) which were all longer than the mean of 280.9 d for Holstein-Friesian sired male calves. Relative to a Holstein-Friesian sire, the odds of dystocia varied from 1.43 (Angus) to 4.77 (Belgian Blue) but, once adjusted for both the estimated maternal genetic merit of the dam and direct genetic merit of the calf for calving difficulty, the range in odds ratios shrunk. A difference of €125.4 existed in calf sale price between the progeny of the different beef breeds investigated which represented over twice the residual standard deviation in calf price within the day of sale-Angus was the cheapest while Charolais calves were, on average, the most expensive calves. Mean carcass weight of steers, not adjusted for age at slaughter or carcass fat, varied from 327.1 kg (Angus) to 363.2 kg (Belgian Blue) for the beef breeds with the mean carcass weight of Holstein-Friesian steer progeny being 322.4 kg. Belgian Blues had, on average, the best carcass conformation with the Herefords and Angus having the worst of all beef breeds. Angus and Hereford steers were slaughtered the youngest of all beef breeds but just 9 d younger than the average of all other beef breeds yet 24 d younger than Holstein-Friesian sired progeny. Clear breed differences in calving and carcass performance exist among beef breeds mated to dairy females. Those breeds excelling in calving performance were not necessarily the best for carcass merit.

A framework for mapping and monitoring human-ocean interactions in near real-time during COVID-19 and beyond.

The human response to the COVID-19 pandemic set in motion an unprecedented shift in human activity with unknown long-term effects. The impacts in marine systems are expected to be highly dynamic at local and global scales. However, in comparison to terrestrial ecosystems, we are not well-prepared to document these changes in marine and coastal environments. The problems are two-fold: 1) manual and siloed data collection and processing, and 2) reliance on marine professionals for observation and analysis. These problems are relevant beyond the pandemic and are a barrier to understanding rapidly evolving blue economies, the impacts of climate change, and the many other changes our modern-day oceans are undergoing. The "Our Ocean in COVID-19″ project, which aims to track human-ocean interactions throughout the pandemic, uses the new eOceans platform (eOceans.app) to overcome these barriers. Working at local scales, a global network of ocean scientists and citizen scientists are collaborating to monitor the ocean in near real-time. The purpose of this paper is to bring this project to the attention of the marine conservation community, researchers, and the public wanting to track changes in their area. As our team continues to grow, this project will provide important baselines and temporal patterns for ocean conservation, policy, and innovation as society transitions towards a new normal. It may also provide a proof-of-concept for real-time, collaborative ocean monitoring that breaks down silos between academia, government, and at-sea stakeholders to create a stronger and more democratic blue economy with communities more resilient to ocean and global change.

Quantifying genetic differences between exported dairy bull calves and those sold for domestic beef production.

Selection bias is introduced when selection among individuals exists but the information used to inform that selection decision is not considered in downstream genetic evaluations. Genetic evaluations are undertaken in several countries for carcass-related metrics in prime cattle; no consideration is generally taken for animals that are harvested at a younger age for veal production and thus do not express the prime carcass phenotype. Although no veal industry exists in Ireland, dairy calves are routinely exported to continental Europe for veal production. The objective of the present study, based on a cross-sectional analysis of calf export data, was to determine quantitatively if genetic variability exists in whether purchased dairy-bred bull calves are immediately exported or retained within the country for domestic production. Also of interest was whether such a genetic difference was associated with differences in carcass weight, conformation score, and fat score in prime cattle relatives. Editing criteria were imposed to consider only Holstein-Friesian bull calves. Post-editing, the fate of 43,890 Holstein-Friesian bull calves (<100 d of age) was available; variance components for the binary phenotype (sold for export or not) were estimated using both linear and threshold animal models, and genetic correlations with carcass traits from 56,366 prime cattle were estimated. The heritability (standard error) of whether or not a calf was exported was 0.04 (0.01) on the linear scale and 0.07 (0.02) on the threshold scale. Although no explicit maternal genetic effect was detected, the proportion of the phenotypic variance due to maternal effects was 0.03 to 0.07. The genetic correlation (standard error) between the export phenotype with carcass weight, conformation score [scale 1 (poor) to 15 (excellent)], and fat score [scale 1 (thin) to 15 (fat)] in prime cattle was 0.002 (0.12), -0.25 (0.12), and -0.32 (0.11), respectively. The low heritability of the calf export phenotype and lack of a strong genetic correlation with carcass metrics suggest that other calf features might be greater determinants of the eventual fate of the calf. Accounting for the export phenotype in genetic evaluations of carcass traits in prime cattle had a negligible effect on the estimated breeding values for carcass merit.

The Neonatal Early Onset Sepsis Calculator; in Clinical Practice.

Aims To determine the impact of applying the Neonatal Early Onset Sepsis Calculator (NEOSC) to clinical practice. We evaluated this multivariable risk prediction model, used in the assessment of infants >35 weeks GA, at risk of neonatal sepsis. Methods A retrospective, cohort study comparing the rates of blood culture use in a large maternity hospital before and after the introduction of the NEOSC. Cases were ascertained from the records of the Department of Microbiology. The key variables were the number of blood cultures (all gestational ages, <72 hours old), infant antibiotic use and sepsis rates. Data for three years prior to NEOSC use (January 2015 - December 2017) were compared with 15 months (January 2018 - Q1 2019) after it was implemented. Results Pre- and post- NEOSC use, the total blood cultures taken annually were: 1,312 (2015), 1,149 (2016), 1,319 (2017) and 702 (2018), 192 (Q1 2019) respectively, a statistically significant reduction [p < 0.00001, 95% CI]. There was no significant difference in rates of either: culture-confirmed GBS-sepsis [p value 0.18, 95% CI] or other-pathogen sepsis [p value 0.32, 95%CI] in term infants between the two periods. There was a significant reduction in antibiotic use in the first 24 hours of life (average 11.3% pre-NEOSC and 5.9% after NEOSC was implemented) [p < 0.00001, 95% CI]. Conclusion The introduction of the NEOSC has reduced blood culture and antibiotic use. This has been achieved without any increase in infection rates.

Choice of artificial insemination beef bulls used to mate with female dairy cattle.

Understanding the preferences of dairy cattle producers when selecting beef bulls for mating can help inform beef breeding programs as well as provide default parameters in mating advice systems. The objective of the present study was to characterize the genetic merit of beef artificial insemination (AI) bulls used in dairy herds, with particular reference to traits associated with both calving performance and carcass merit. The characteristics of the beef AI bulls used were compared with those of the dairy AI bulls used on the same farms. A total of 2,733,524 AI records from 928,437 females in 5,967 Irish dairy herds were used. Sire predicted transmitting ability (PTA) values and associated reliability values for calving performance and carcass traits based on national genetic evaluations from prior to the insemination were used. Fixed effects models were used to relate both genetic merit and the associated reliability of the dairy and beef bulls used on the farm with herd size, the extent of Holstein-Friesian × Jersey crossbreeding adopted by the herd, whether the herd used a technician insemination service or do-it-yourself, and the parity of the female mated. The mean direct calving difficulty PTA of the beef bulls used was 1.85 units higher than that of the dairy bulls but with over 3 times greater variability in the beef bulls. This 1.85 units equates biologically to an expectation of 1.85 more dystocia events per 100 dairy cows mated in the beef × dairy matings. The mean calving difficulty PTA of the dairy AI bulls used reduced with increasing herd size, whereas the mean calving difficulty PTA of the beef AI bulls used increased as herd size increased from 75 cows or fewer to 155 cows; the largest herds (>155 cows) used notably easier-calving beef bulls, albeit the calving difficulty PTA of the beef bulls was 3.33 units versus 1.67 units for the dairy bulls used in these herds. Although we found a general tendency for larger herds to use dairy AI bulls with lower reliability, this trend was not obvious in the beef AI bulls used. Irrespective of whether dairy or beef AI bulls were considered, herds that operated more extensive Holstein-Friesian × Jersey crossbreeding (i.e., more than 50% crossbred cows) used, on average, easier calving, shorter gestation-length bulls with lighter expected progeny carcasses of poorer conformation. Mean calving difficulty PTA of dairy bulls used increased from 1.39 in heifers to 1.79 in first-parity cows and to 1.82 in second-parity cows, remaining relatively constant thereafter. In contrast, the mean calving difficulty PTA of the beef bulls used increased consistently with cow parity. Results from the present study demonstrate a clear difference in the mean acceptable genetic merit of beef AI bulls relative to dairy AI bulls but also indicates that these acceptable limits vary by herd characteristics.

Genetic selection for hoof health traits and cow mobility scores can accelerate the rate of genetic gain in producer-scored lameness in dairy cows.

Cattle breeding programs that strive to reduce the animal-level incidence of lameness are often hindered by the availability of informative phenotypes. As a result, indicator traits of lameness (i.e., hoof health and morphological conformation scores) can be used to improve the accuracy of selection and subsequent genetic gain. Therefore, the objectives of the present study were to estimate the variance components for hoof health traits using various phenotypes collected from a representative sample of Irish dairy cows. Also of interest to the present study was the genetic relationship between both hoof health traits and conformation traits with producer-scored lameness. Producer-recorded lameness events and linear conformation scores from 307,657 and 117,859 Irish dairy cows, respectively, were used. Data on hoof health (i.e., overgrown sole, white line disease, and sole hemorrhage), mobility scores, and body condition scores were also available from a research study on up to 11,282 Irish commercial dairy cows. Linear mixed models were used to quantify variance components for each trait and to estimate genetic correlations among traits. The estimated genetic parameters for hoof health traits in the present study were greater (i.e., heritability range: 0.005 to 0.27) than previously reported in dairy cows. With the exception of analyses that considered hoof health traits in repeatability models, little difference in estimated variance components existed among the various hoof-health phenotypes. Results also suggest that producer-recorded lameness is correlated with both hoof health (i.e., genetic correlation up to 0.48) and cow mobility (i.e., genetic correlation = 0.64). Moreover, cows that genetically tend to have rear feet that appear more parallel when viewed from the rear are also genetically more predisposed to lameness (genetic correlation = 0.39); genetic correlations between lameness and other feet and leg type traits, as well as between lameness and frame type traits, were not different from zero. Results suggest that if the population breeding goal was to reduce lameness incidence, improve hoof health, or improve cow mobility, genetic selection for either of these traits should indirectly benefit the other traits. Results were used to quantify the genetic gains achievable for lameness when alternative phenotypes are available.

Client personal recovery and recovery orientation of an Irish suicide intervention charity.

BACKGROUND: Recovery is a key goal for individuals, and services' recovery orientation can facilitate this process. The independent mental health sector is increasingly important in Ireland, particularly in counselling and suicide prevention. We aimed to evaluate Pieta House as a recovery-oriented service through clients' self-rated recovery; and clients' and therapists' evaluation of the service. METHODS: Clients completing therapy over a 3-month period were invited to complete the Recovery Assessment Scale (RAS) and the Recovery Self Assessment-Revised (RSA-R). Therapists completed the RSA-R staff version. RESULTS: Response rate was 36.7% for clients (n=88), 98% for therapists (n=49). Personal recovery was endorsed by 73.8% of clients, with highest agreement for factors 'Willingness to Ask for Help' (84.5%), and 'Reliance on Others' (82.1%). A smaller number agreed with factors 'Personal Confidence and Hope' (61.3%) and 'No Domination by Symptoms' (66.6%). Clients' and therapists' evaluation of the service showed high levels of agreement with factors of 'Choice' (90.9% clients, 100% therapists); 'Life Goals' (84.1% clients, 98% therapists) and 'Individually Tailored Services' (80.6% clients, 79.6% therapists). Client involvement in service management had the lowest level of agreement (36.4% clients, 30.6% therapists). Clients' self-rated recovery correlated with their rating of the service (correlation value 0.993, p=0.01). CONCLUSIONS: Clients' self-rated recovery and the recovery orientation of Pieta House were rated highly, with areas for improvement in service user involvement, peer support and advocacy. The correlation of personal recovery and recovery orientation of the service may merit further study.

Genetic parameters for both a liver damage phenotype caused by and antibody response to phenotype in dairy and beef cattle.

is a helminth parasite of economic importance to the global cattle industry, with documented high international herd prevalence. The objective of the present study was to generate the first published genetic parameter estimates for liver damage caused by as well as antibody response to in cattle. Abattoir data on the presence of live , or -damaged livers, were available between the years 2012 and 2015, inclusive. A second data set was available on cows from 68 selected dairy herds with a blood ELISA test for antibody response to in autumn 2015. Animals were identified as exposed by using herd mate phenotype, and only exposed animals were retained for analysis. The abattoir data set consisted of 20,481 dairy cows and 75,041 young dairy and beef animals, whereas the study herd data set consisted of 6,912 dairy cows. (Co)variance components for phenotypes in both data sets were estimated using animal linear mixed models. Fixed effects included in the model for both data sets were contemporary group, heterosis coefficient, recombination loss coefficient, parity, age relative to parity/age group, and stage of lactation. An additional fixed effect of abattoir by date of slaughter was included in the model for the analysis of the abattoir data. Direct additive genetic effects and a residual effect were included as random effects for all analyses. After data edits, the prevalence of liver damage caused by in cows and young cattle was 47% and 20%, respectively. The prevalence of a positive antibody response to in cows from the study herd data was 36% after data edits. The heritability of as a binary trait for dairy cows in abattoir data and study herd data was 0.03 ± 0.01 and 0.09 ± 0.02, respectively; heritability in young cattle was 0.01 ± 0.005. The additive genetic SD of as a binary trait was 0.069 and 0.050 for cows and young cattle from the abattoir data, respectively, and 0.112 from the study herd cows. The genetic correlation between liver damage caused by in young cattle and cows from the abattoir data was 0.94 ± 0.312 and the genetic correlation between liver damage caused by in cows and positive antibody response to in cows in the study herd data was 0.37 ± 0.283.

Standardised versus Individualised Parenteral Nutrition. Further Food for Thought.

Parenteral Nutrition may be prescribed as a standard PN (SPN) formulation or as an individualised PN (IPN) formulation. SPN may have advantages in terms of rapid availability, less prescription errors, decreased risk of infection and cost savings but IPN, specifically tailored to an infants needs, may achieve better outcomes in terms of nutrient intake and weight gain. The aim of our study was to determine if VLBW infants in our NICU benefited from receiving IPN over currently available SPN solutions. Our findings were that VLBW infants prescribed IPN received significantly more amino acid (28%), glucose (6%), energy (11%) and calcium (8%) from the aqueous phase of PN than had they received a similar volume of SPN. The benefits were seen over all the days for which PN was administered. In conclusion, IPN was found to offer significant benefits to our VLBW infants. Modifications to currently available SPN would result in better SPN formulations. Our study also supported the recent recommendation to reduce the calcium:phosphate ratio in PN solutions to avoid early hypophosphataemia.

The National Neonatal Transport Programme (NNTP) 2004-2009.

A retrospective analysis of all National Neonatal Transport Programme (NNTP) transport data from 2004-2009 was performed. 1621 transports were conducted during this period with a yearly average of 271. The majority (96%) were ground transports. 1118 (69%) were forward transfers. Of the 446 (27.5%) retrotransfers, 411 (91%.) were to tertiary centres. When transported, 592 infants (36.5%) were <48 hours old and 770 (47.5%) were <1 week old. 902 transports (55%) involved infants <32 wks birth-gestation and 720 (44%) involved infants weighing <1500gms. Transport for management of patent ductus arteriosus accounted for 357 (22%). The average mobilisation time was 34 minutes. 54% of transports were completed after scheduled service hours. The NNTP currently transports similar numbers of critically ill infants during its 8hr service compared with neonatal transport services that operate 24hr services. Performing PDA ligations in a tertiary neonatal unit would significantly reduce the number of neonatal transports required annually.

H1N1 infection in emergency surgery: A cautionary tale.

Pandemic 2009 influenza A H1N1 has spread rapidly since its first report in Mexico in March 2009. This is the first influenza pandemic in over 40 years and it atypically affects previously healthy young adults, with higher rates of morbidity and mortality. The medical literature has been inundated with reports of H1N1 infection, the majority found in critical care and internal medicine journals with a relative paucity in the surgical literature. Despite this, it remains an important entity that can impact greatly on acute surgical emergencies. We present a case of previously healthy 31-year-old male who underwent open appendectomy. His post-operative recovery was complicated by acute respiratory distress syndrome secondary to H1N1 infection. This case report highlights the impact that H1N1 virus can have on acute surgical emergencies and how it can complicate the post-operative course.

Persistent vancomycin and high-level gentamicin-resistant Enterococcus faecium bacteremia and intra-aortic thrombus in an extremely low birth-weight infant.

Vancomycin-resistant Enterococcus (VRE) sepsis is emerging as a significant problem in the intensive care setting. The treatment at any age is challenging, but there is a dearth of information on this infection and its treatment in the very premature infant. We describe successful treatment of persistent bacteremia caused by Enterococcus faecium with vancomycin and high-level gentamicin resistance in a 10-day-old former 23-week premature male infant.

Efficacy of intravenous immunoglobulin in the management of haemolytic disease of the newborn.

Intravenous immunoglobulin (IVIG) is indicated for use in Rhesus and ABO hemolytic disease of the newborn (HDN) to reduce the need for exchange transfusion, to decrease hospital stay and the duration of phototherapy. 11 infants received IVIG and the effect of IVIG on the total serum bilirubin (TSB) level, and its effect on the rate of rise of TSB was quantified. There was a statistically significant decrease in bilirubin levels before and after treatment with IVIG from 234 to 219 micromol/L (p = 0.001). In addition, the rate of change in bilirubin level significantly altered from an upward to a downward trend. (p = 0.001). The Number Needed to Treat (NNT) to prevent an exchange transfusion was 2.75--comparable with the recent systematic review of IVIG with a NNT of 2.7.