Subject(s)
Embryo Transfer , Fertilization in Vitro , Pregnancy, Ectopic/etiology , Pregnancy , Adult , Female , HumansSubject(s)
Adenoma/metabolism , Bromocriptine/therapeutic use , Infertility, Male/drug therapy , Pituitary Neoplasms/metabolism , Prolactin/metabolism , Adenoma/complications , Adult , Chorionic Gonadotropin/therapeutic use , Drug Resistance , Humans , Infertility, Male/etiology , Male , Menotropins/therapeutic use , Pituitary Neoplasms/complicationsABSTRACT
The outcome of pregnancy following amniocentesis was studied prospectively in 517 consecutive patients undergoing amniocentesis in a single centre. The outcome in 289 of these pregnancies was compared with that in 289 control patients strictly matched for social class, age and parity. There were no significant differences in fetal loss, perinatal mortality or vaginal bleeding between the amniocentesis and control groups. There were significantly more congenital abnormalities in the amniocentesis group (P less than 0.01). These appear to be associated with the amniocentesis procedure and not with the occurrence of raised maternal serum alpha-fetoprotein levels. Although there was an increased risk of preterm delivery (P less than 0.02) there was no significant difference in the distribution of birthweights by centiles for gestational age between amniocentesis and control groups. There was a significant association between intrauterine growth retardation and raised serum alpha-fetoprotein (P less than 0.005). It is concluded that where the indications are strong, amniocentesis continues to be justified.
Subject(s)
Amniocentesis/adverse effects , Abortion, Spontaneous/etiology , Adolescent , Adult , Birth Weight , Chromosome Aberrations/diagnosis , Chromosome Disorders , Clinical Trials as Topic , Congenital Abnormalities/epidemiology , Female , Fetal Death/etiology , Gestational Age , Humans , Infant, Newborn , Maternal Age , Obstetric Labor, Premature , Pregnancy , Pregnancy Trimester, Second , Pregnancy, High-Risk , Prospective Studies , Uterine Hemorrhage/etiologyABSTRACT
A case of hyperemesis gravidarum at 9 weeks' gestation is described for which no cause could initially be found. Intravenous feeding was needed as a life preserving measure and following improvement on this regime the patient went into a thyrotoxic crisis which was successfully diagnosed and treated. The continuing pregnancy and its outcome is described. The need for practitioners to remember vomiting as a presenting sign of thyrotoxicosis is stressed.
Subject(s)
Hyperemesis Gravidarum/etiology , Hyperthyroidism/complications , Pregnancy Complications , Adult , Female , Humans , Hyperemesis Gravidarum/therapy , Hyperthyroidism/drug therapy , Parenteral Nutrition , Pregnancy , Propranolol/therapeutic use , Thyroid Crisis/drug therapyABSTRACT
PIP: Plasma levels of progesterone and estradiol-17beta were measured using radioimmunoassay methods in 52 blood samples obtained from 10 women aborting after intraamniotic instillation of prostaglandin F2alpha. Mean falls in plasma progesterone of 55.7% and in estradiol-17beta of 46.6% were noted. There was a highly significant correlation between falling concentrations of both steroids and the instillation-abortion interval (p 0.001).^ieng
Subject(s)
Abortion, Induced , Estradiol/blood , Progesterone/blood , Prostaglandins/therapeutic use , Adolescent , Adult , Amnion , Female , Humans , Pregnancy , Radioimmunoassay , Time Factors , Uterus/physiologySubject(s)
Anesthesia, Epidural , Anesthesia, Obstetrical , Bupivacaine/blood , Uterus/drug effects , Adult , Blood Pressure , Body Height , Body Weight , Bupivacaine/pharmacology , Female , Gestational Age , Heart Rate , Humans , Pregnancy , UltrasonicsSubject(s)
Abortion, Induced , Progesterone/blood , Sodium Chloride/administration & dosage , Adolescent , Adult , Female , Humans , Hypertonic Solutions , Pregnancy , Radioligand Assay , Time FactorsABSTRACT
The effect of orciprenaline on uterine activity in 10 women in early induced labour at term with intact membranes was studied. Nine had uterine contractions in response to intravenous oxytocin and one to prostaglandin E(2). The inhibition of uterine contractility was dose-dependent. The effective dose varied between 10 and 20 mug/minute. Tachyphylaxis was not observed. The only significant effects noted in the mother were tachycardia and increased pulse pressure and in the fetus a smaller increase in heart rate.
Subject(s)
Labor, Induced , Phenethylamines/administration & dosage , Resorcinols/administration & dosage , Uterus/drug effects , Adult , Female , Fetal Heart/drug effects , Heart Rate/drug effects , Humans , Injections, Intravenous , Metaproterenol/administration & dosage , Muscle Contraction/drug effects , Pregnancy , Prostaglandins , Pulse/drug effectsABSTRACT
The use of orciprenaline, a beta-adrenergic agent, in 30 patients with probable premature labour proved to be effective and safe to both mother and fetus under the conditions employed.
