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Bioorg Med Chem Lett
; 16(13): 3489-94, 2006 Jul 01.
Article
in English
| MEDLINE
| ID: mdl-16632357
ABSTRACT
Synthesis and derivatization of a series of substituted tetrahydrofluorenone analogs giving potent, ERbeta subtype selective ligands are described. Several analogs possessing ERbeta binding affinities comparable to 17beta-estradiol but with greater than 75-fold selectivity over ERalpha are reported.