ABSTRACT
Uptake of (+/-)-[3H]-noradrenaline, [14C]-bretylium and [125I]-o-iodobenzyltrimethylammonium iodide (RIBA) by rat heart was studied by the Langendorff technique. All three compounds showed significant uptake. 2 Corticosterone and 17-beta-oestradiol inhibited the uptake of all three compounds by rat heart, a finding consistent with extraneuronal uptake (uptake2). 3 [131I]-RIBA was injected intravenously into pigs and monkeys (M. speciosus). Myocardial samples taken from pigs killed 1 and 2 h after injection showed significant uptake. No significant uptake was found in myocardial samples of monkeys killed 10 min, 2 h and 24 h, respectively, after injection. 4 Four normal human volunteers received [125I]-RIBA intravenously and the image of the precordial area was followed by means of scintillation camera for the first 4 h after injection. In two of the subjects, the scintigrams were repeated at 22 and 23 h after injection, respectively. No evidence of myocardial uptake was observed. 5 These results suggest the possibility that man and at least one other primate species may differ from lower species with regard to uptake.
Subject(s)
Bretylium Compounds/metabolism , Myocardium/metabolism , Adult , Animals , Female , Haplorhini , Humans , In Vitro Techniques , Iodobenzenes/metabolism , Macaca , Male , Norepinephrine/metabolism , Rats , Species Specificity , SwineABSTRACT
Twenty-three patients with clinical Stage IA-IIIB Hodgkin disease underwent extended-field radiotherapy, including the intact spleen. In 17 of those patients, there was little evidence of renal dysfunction resulting from partial irradiation of the left kidney, which is inherent in such treatment. While isotopic images revealed an anatomic defect in the upper pole of the left kidney in one-third of the patients, dynamic studies showed that this anatomic alteration was not accompanied by any demonstrable dysfunction. Consistently normal serum BUN and creatinine levels in all patients tended to affirm that conclusion.
Subject(s)
Abdominal Neoplasms/radiotherapy , Hodgkin Disease/radiotherapy , Kidney/radiation effects , Radiation Injuries , Radiotherapy, High-Energy/adverse effects , Splenic Neoplasms/radiotherapy , Abdominal Neoplasms/mortality , Adolescent , Adult , Aged , Blood Urea Nitrogen , Child , Creatinine/blood , Female , Follow-Up Studies , Hodgkin Disease/mortality , Humans , Kidney/diagnostic imaging , Kidney/physiopathology , Kidney Function Tests , Male , Methods , Middle Aged , Radiation Injuries/diagnosis , Radiation Injuries/physiopathology , Radiation Protection , Radionuclide Imaging , Splenic Neoplasms/mortalityABSTRACT
The authors compared radionuclide cerebral dynamic studies, brain scans, and clinical evaluation as indicators of recurrence of intracranial anaplastic gliomas and found cerebral dynamic studies more sensitive to tumor growth than static brain scans. The former may show changes prior to clinical evidence of tumor progression.
Subject(s)
Brain Neoplasms/physiopathology , Cerebral Cortex/diagnostic imaging , Cerebrovascular Circulation , Glioblastoma/diagnosis , Neoplasm Recurrence, Local/diagnostic imaging , Blood-Brain Barrier , Brain/blood supply , Brain Mapping , Cerebral Angiography , Glioblastoma/drug therapy , Glioblastoma/mortality , Humans , Infusions, Parenteral , Life Expectancy , Neurologic Examination , Prognosis , Radionuclide Imaging , Scintillation Counting/instrumentation , Technetium/administration & dosageABSTRACT
The definitive diagnosis of pulmonary embolism remains difficult despite recent advances in nuclear medicine and angiography. In 10% of a selected series of 145 patients a negative chest x-ray and a positive lung scan was associated with no arteriographic evidence of pulmonary emboli. A normal perfusion lung scan excludes significant pulmonary embolism. When pulmonary arteriography is necessary, a biplane selective pulmonary angiogram should be performed and subselective injections may be required. Pulmonary arteriography is less of a threat to a patient suspected of having pulmonary embolic disease than inappropriate treatment.
Subject(s)
Angiography , Pulmonary Artery/diagnostic imaging , Pulmonary Embolism/diagnosis , Radionuclide Imaging , Female , Humans , Middle Aged , Pulmonary Embolism/diagnostic imaging , Radionuclide Imaging/methodsABSTRACT
A technique for analysis of dynamic radionuclide studies of the cerebral circulation is described. This technique permits objective classification of observed radionuclide distribution patterns. Variation in the time-to-peak activity, and in the maximum attained activity as determined by region-of-interest analysis of cerebral hemispheric activity, was defined for a normal population. Application of these normal values permits classification of observed hemispheric radionuclide distribution patterns in anaplastic gliomas and in occlusive cerebrovascular disease. Radionuclide activity in gliomas may be normal, decreased, or increased in the region of the tumor. In cerebrovascular occlusion, decreased activity, associated with a delay in time-to-peak activity, is frequently demonstrated in the affected hemisphere.
