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Bull Exp Biol Med ; 152(1): 25-7, 2011 Nov.
Article in English, Russian | MEDLINE | ID: mdl-22803031

ABSTRACT

Venous hypertension and swelling of the hind limbs was demonstrated to develop in rat model of chronic venous insufficiency. It was found that 14-day course of dihydroquercetin (50 mg/kg) and lipoic acid (50 mg/kg) administered intragastrically prevented the increase in hind limb volume and reduced the severity of edema of rat muscle tissue in chronic venous insufficiency.


Subject(s)
Antioxidants/pharmacology , Quercetin/analogs & derivatives , Thioctic Acid/pharmacology , Venous Insufficiency/drug therapy , Animals , Chronic Disease , Edema/etiology , Edema/prevention & control , Hindlimb/blood supply , Hindlimb/pathology , Male , Muscle, Skeletal/blood supply , Muscle, Skeletal/pathology , Quercetin/pharmacology , Rats , Rats, Wistar , Statistics, Nonparametric , Venous Insufficiency/complications
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