Subject(s)
Acidosis, Renal Tubular/complications , Nephrocalcinosis/complications , Polycythemia/etiology , Adult , Humans , MaleABSTRACT
Successful renal transplantation has a favourable effect on the development of ocular disorders in periodic haemodialysis patients. Certain complications arise in the eyes of the recipients and are attributed mainly to the immunosuppressive medication. The purpose of our study was the recording of the ocular complications in patients with successful renal transplants after long-term stabilization of renal function and immunosuppressive therapy.
Subject(s)
Eye Diseases/etiology , Kidney Transplantation/adverse effects , Kidney Transplantation/pathology , Adult , Aged , Eye Diseases/classification , Eye Diseases/epidemiology , Female , Fluorescein Angiography , Greece , Humans , Incidence , Male , Middle AgedABSTRACT
Biotin in high doses was given for 1-2 years to three diabetic patients suffering from severe diabetic peripheral neuropathy. Within 4-8 weeks there was a marked improvement in clinical and laboratory findings. It is suggested that in diabetes may exist a deficiency, inactivity or unavailability of Biotin, resulting in disordered activity of biotin-dependent enzyme, pyruvate carboxylase, leading to accumulation of pyruvate and/or depletion of aspartate, both of which play a significant role in nervous system metabolism. Based on our good results, regular biotin administration could be suggested for every diabetic patient for the prevention and management of peripheral neuropathy although extensive randomised clinical trials are required.
Subject(s)
Biotin/therapeutic use , Diabetic Neuropathies/drug therapy , Action Potentials , Adult , Aged , Biotin/metabolism , Diabetes Mellitus/drug therapy , Diabetes Mellitus/metabolism , Diabetic Neuropathies/metabolism , Diabetic Neuropathies/physiopathology , Humans , Male , Middle Aged , Neural ConductionABSTRACT
Fifteen normal pregnant women were studied. Serial measurements of serum total, free and bound uric acid and their clearances were done in early (10-20 weeks), mid- (20-30 weeks) and advanced (30-40 weeks) pregnancy, and after delivery (4-5 weeks). The following was observed. 1. A decrease in early and mid-pregnancy of total and free uric acid (p less than 0.001). 2. A gradual increase from the early to advanced pregnancy of bound uric acid (p less than 0.001). 3. An increase in early and mid-pregnancy of total uric acid clearance and a similar but more pronounced increase of free uric acid clearance (p less than 0.001). These findings explain many differences in previous conflicting reports concerning the metabolic behavior of uric acid, and place future investigation thereof on a more promising basis in normal and abnormal pregnancy.
Subject(s)
Pregnancy/blood , Uric Acid/blood , Adolescent , Adult , Female , Humans , Postpartum Period/bloodABSTRACT
In 92 uremic patients under chronic hemodialysis without ascorbic acid supplementation, serum ascorbic acid was measured before hemodialysis and between two sessions. The results indicated a more serious ascorbic acid deficiency of patients than in previous studies. This difference might be explained by the highly specific enzymatic method applied in the present study, excluding any potential interference of various serum reducing substances.
Subject(s)
Ascorbic Acid Deficiency/etiology , Renal Dialysis/adverse effects , Adult , Aged , Ascorbic Acid/blood , Female , Humans , Male , Middle AgedABSTRACT
Serum ferroxidase I (ceruloplasmin) and ferroxidase II activities were studied in 49 uremic patients under conservative treatment, in 79 patients undergoing hemodialysis and in 56 healthy subjects, as controls. Ferroxidase I was significantly higher in both groups of patients. Ferroxidase II was significantly elevated only in patients undergoing chronic hemodialysis. The cause of this difference is not clear, but seems to be of considerable interest.
