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Vet Pathol ; 49(5): 771-4, 2012 Sep.
Article in English | MEDLINE | ID: mdl-21900543

ABSTRACT

Lymphoma in the left femoral nerve of a 10-year-old English Cocker Spaniel caused complete paralysis of the affected limb. Neoplastic cells were immunopositive for CD79a and Pax5 and negative for CD3. Neoplastic cells were in multiple lymph nodes and one kidney but spared bone marrow. The clinical and histologic features in this case resemble those of the rare human condition of neurolymphomatosis.


Subject(s)
Dog Diseases/diagnosis , Femoral Nerve/pathology , Lymphoma, B-Cell/veterinary , Peripheral Nervous System Diseases/veterinary , Animals , CD79 Antigens/immunology , Diagnosis, Differential , Dog Diseases/immunology , Dog Diseases/pathology , Dogs , Extremities/pathology , Fatal Outcome , Female , Femoral Artery/pathology , Immunohistochemistry/veterinary , Immunophenotyping/veterinary , Kidney/pathology , Lymph Nodes/immunology , Lymph Nodes/pathology , Lymphoma, B-Cell/diagnosis , Lymphoma, B-Cell/immunology , Lymphoma, B-Cell/pathology , Neoplastic Cells, Circulating/pathology , PAX5 Transcription Factor/immunology , Paralysis , Peripheral Nervous System Diseases/diagnosis , Peripheral Nervous System Diseases/immunology , Peripheral Nervous System Diseases/pathology
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